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2 3 benzofuran/рак
Линкът е запазен в клипборда
Страница 1 от 16 резултата
(S,E)-3-(6-aminopyridin-3-yl)-N-((5-(4-(3-fluoro-3-methylpyrrolidine-1-car- bonyl)phenyl-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide for the treatment of cancer
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BACKGROUND OF THE INVENTION
Cancer remains a disease for which existing treatments are insufficient. For example, it is expected that by the end of 2015, more than 1.6 million new cases of cancer will be diagnosed and close to 600,000 people will die from the disease. While major breakthroughs are
Administration regime for N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2- ylcarbonylamino]ethoxy}benzamide
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for N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylami- no]ethoxy}benzamide of formula (I):
##STR00002##
or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy,
Methods for treating resistant tumors
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BACKGROUND OF THE INVENTION
Along with surgery and radiotherapy, chemotherapy continues to be an effective therapy for many cancers. In fact, several types of cancer are now considered to be curable by chemotherapy and include Hodgkin's disease, large cell lymphoma, acute lymphocytic leukemia,
Aplha-substituted-3-benzyl-benzofurans
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FIELD OF THE INVENTION
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are .alpha.-substituted with ether, thioether, amine, hydrazine, cyano, or halo, which are useful for the treatment of the various medical indications
.alpha.-substituted-3-benzyl-benzofurans
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FIELD OF THE INVENTION
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are .alpha.-substituted with ether, thioether, amine, cyano, or halo, which are useful for the treatment of the various medical indications associated
Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
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FIELD OF THE INVENTION
This invention pertains to compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein, compositions containing the compounds, and methods of treating cancer involving over-expressed or dysregulated Mcl-1
Benzofuran carboxamides and their therapeutic use
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FIELD OF THE INVENTION
The present invention relates to novel benzofuran carboxamides, and to their formulation and use as pharmaceuticals.
BACKGROUND OF THE INVENTION
EP-A-0637586 discloses benzofuran derivatives, including 4-carboxamides, as acetylcholine esterase inhibitors.
WO-A-9408962
Benzofuran-3-yl(indol-3-yl) maleimides as potent GSK3 inhibitors
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BACKGROUND OF THE INVENTION
The search for new therapeutic agents has been greatly aided in recent years by better understanding of the structure of enzymes and other biomolecules associated with target diseases. One important class of enzymes that has been the subject of extensive study is the
Benzofuran derivative
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TECHNICAL FIELD
The present invention relates to a benzofuran derivative which exhibits excellent inhibitory effect against production of tumor necrosis factor (TNF-.alpha.) and high absorption after oral administration, and thus is useful for preventing or treating allergic diseases, immune
Polysubstituted benzofurans and medicinal applications thereof
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is filed under the provisions of 35 U.S.C. .sctn.371 and claims the priority of International Patent Application No. PCT/EP2011/057502 filed on 10 May 2011 entitled "Polysubstituted Benzofurans and Medicinal Applications Thereof" in the name
Benzofuran compound and pharmaceutical composition containing the same
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TECHNICAL FIELD
The present invention relates to a benzofuran compound having a leukotriene (particularly leukotriene B4) inhibitory activity, a pharmaceutically acceptable salt thereof and prodrugs thereof. Moreover, the present invention relates to a pharmaceutical composition comprising the
Cyanine-sulfenates for dual phototherapy
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FIELD OF THE INVENTION
The present invention relates to novel dye-sulfenate compounds, and to phototherapeutic procedures using these compounds.
BACKGROUND OF THE INVENTION
The use of visible and near-infrared (NIR) light in clinical practice is growing rapidly. Compounds absorbing or emitting in
Methods for reversing multidrug resistance
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BACKGROUND OF THE INVENTION
Along with surgery and radiotherapy, chemotherapy continues to be an effective therapy for many cancers. In fact, several types of cancer are now considered to be curable by chemotherapy and include Hodgkin's disease, large cell lymphoma, acute lymphocytic leukemia,
Salts and polymorphs of a VEGF-R inhibitor
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BACKGROUND OF THE INVENTION
This invention relates to salt forms and polymorphs of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carbo- xamide that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to compositions
Amino-and mercurio-substituted 4',5'-dihydropsoralens and therapeutical uses thereof
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FIELD OF THE INVENTION
This invention relates to amino- and mercurio-substituted 4',5'-dihydropsoralens and 2-substituted mercurimethyl-2-3-dihydro-benzofurans and their use as phototherapeutics. Methods for preparing the amino- and mercurio-substituted 4',5'-dihydropsoralens and the 2-substituted
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