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adriamycin/атрофия

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Страница 1 от 218 резултата

Effects of anti-hyperlipidaemic agent or dietary protein restriction on progressive renal deterioration in adriamycin-induced nephropathy in rats.

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Hyperlipidaemia is strongly suggested to contribute to the pathogenesis of glomerular sclerosis. This study intends to clarify the effects of either a lipid lowering agent, lovastatin (LO) or protein restriction (PR) on adriamycin (ADR)-induced progressive glomerular sclerosis in rats. During the

Schwann cell degeneration induced by doxorubicin (adriamycin).

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Doxorubicin is an anthracycline antineoplastic antibiotic that acts at the cell nucleus by intercalating between base pairs of DNA, thus inhibiting DNA-directed mRNA synthesis. Intraneural micro-injection of 0.19-0.38 micrograms of this substance into rat sciatic nerve results in a delayed subacute

[Changes in phase analysis without deterioration of the isotopic ejection fraction of the left ventricle in patients treated with adriamycin].

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Sequential study on the influence of adriamycin on cell proliferation and ultrastructure of cultured mammary tumor cells.

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The time-dependent cytocidal and growth inhibitory effects of Adriamycin (ADM) on monolayer cultures of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor cells were analyzed. The inhibitory effect on cell proliferation was assessed by colony formation in soft agar. Growth inhibition and

Deterioration of previous acute lung injury during neutropenia recovery.

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METHODS Although neutropenia recovery is associated with a high risk of deterioration of respiratory condition, no studies designed to identify risk factors for acute respiratory distress syndrome (ARDS) in this situation have been published. METHODS Medical ICU in a French teaching

Adriamycin-induced cardiomyopathy in the dog--an appropriate model for research on partial left ventriculectomy?

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OBJECTIVE To evaluate the adriamycin-induced cardiomyopathy in the dog for research on partial left ventriculectomy (PLV). METHODS An intracoronary catheter was introduced into the left main stem via the first diagonal branch in a retrograde fashion in 6 adult FBI (Foxhound Boehringer Ingelheim)

Partial left ventriculectomy in modified adriamycin-induced cardiomyopathy in the dog.

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BACKGROUND The purpose of this study was to evaluate modified adriamycin-induced cardiomyopathy in the dog for research on partial left ventriculectomy (PLV). METHODS An intracoronary catheter was introduced into the left main stem via the first marginal branch in a retrograde fashion in 12 adult

Animal models of amyotrophic lateral sclerosis and the spinal muscular atrophies.

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The causes of human amyotrophic lateral sclerosis (ALS) and the spinal muscular atrophies (SMA) are, almost without exception, unknown. This ignorance has stimulated the search for animal models to obtain insight into the etiology, pathogenesis and biochemical mechanisms underlying the human

The evolution of cellular degeneration in dorsal root ganglia exposed to doxorubicin in tissue culture.

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Doxorubicin (Adriamycin) is a drug having both antibiotic and antimitotic properties. It intercalates between base pairs of DNA causing breaks in the helical strands. It is widely used as a cancer chemotherapeutic agent but is limited in use by a dose-related cardiomyopathy and necrosis of

Protection from adriamycin-induced cardiomyopathy in rats.

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The use of adriamycin, one of the most potent antineoplastic agents available causes a dose dependent cardiomyopathy. Carnitine does play a central role in myocardial metabolism by controlling fatty acid oxidation and the acetyl-CoA pool. Protective effects of carnitine have been described in

[Drug-induced myocardial disease--adriamycin cardiotoxicity].

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Myocardial damage may be induced by several categories of drugs. Adriamycin is one of the most effective chemotherapeutic agents. Unfortunately, it develops a distinctive and life-threatening congestive heart failure by well-characterized, dose-dependent cardiac toxicity. Left ventricular ejection

Acute adriamycin cardiotoxicity: morphologic alterations in isolated perfused rabbit heart.

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Adriamycin is an antitumor agent whose use is limited by cardiac toxicity resulting in a late congestive cardiomyopathy. The time course of the cardiac changes and whether they are due to direct effect of the drug on the myocyte is unknown. The purpose of this study was to determine the very early

Effects of captopril and hydralazine on progression of adriamycin nephropathy in spontaneously hypertensive rats.

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The effects of captopril and hydralazine on morphologic changes and clinical course of adriamycin nephropathy in spontaneously hypertensive rats (SHR) were examined. The rats were followed for 18 weeks after adriamycin injections. At week 1 they were randomly assigned to receive no antihypertensive

Pre- and co-treatment with xanthophyll enhances the anti-leukemic activity of adriamycin.

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Xanthophyll (lutein) is one of the most potent known antioxidants. It has been shown that dietary intake of xanthophyll helps to prevent age-related macular degeneration and the development of cataracts. It may also reduce the risk of developing various types of cancer. Here we showed that

Electrochemical treatment of cancer. II: Effect of electrophoretic influence on adriamycin.

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Electrochemical treatment of cancer with DC electrodes changes the microenvironment of the cancer cells by electrophoresis. They may deteriorate and resorb. In larger neoplasms, the effects can be enhanced by electrophoresis of a chemotherapeutic agent. Adriamycin delivered into an electropositive
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