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adriamycin/възпаление

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3-(arylsulfonylamino)-tetrahydropyran-3-carboxylic acid hydroxamides

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BACKGROUND OF THE INVENTION The present invention relates to 3-(arylsulfonylamino)-tetrahydropyran-3-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment of inflammation, cancer as well as other disorders. The compounds of the present invention are

Gem substituted hydroxamic acids

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BACKGROUND OF THE INVENTION The present invention relates to geminal disubstituted cyclic hydroxamic acids and derivatives thereof, and to pharmaceutical compositions comprising such derivatives and to the use of such derivatives in the treatment of arthritis, cancer and other diseases. The present

3-(arylsulfonylamino)-tetrahydrofuran-3-carboxylic acid hydroxamides

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BACKGROUND OF THE INVENTION The present invention relates to 3-(arylsulfonylamino)-tetrahydrofuran-3-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment of inflammation, cancer and other disorders. The compounds of the present invention are inhibitors

Cyclic sulfone derivatives

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BACKGROUND OF THE INVENTION The present invention relates to cyclic sulfone derivatives which are inhibitors a matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of arthritis, cancer,

Arylsulfonylamino hydroxamic acid derivatives

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BACKGROUND OF THE INVENTION The present invention relates to arylsulfonylamino hydroxamic acid derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of

Arylsulfonylamino hydroxamic acid derivatives

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The present invention relates to arylsulfonylamino hydroxamic acid derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue

Arylsulfonyl hydroxamic acid derivatives

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BACKGROUND OF THE INVENTION The present invention relates to arylsulfonyl hydroxamic acid derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of

(4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides

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BACKGROUND OF THE INVENTION The present invention relates to (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment. The compounds of the present invention are inhibitors of zinc metalloendopeptidases, especially

Phosphinate based inhibitors of matrix metalloproteases

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BACKGROUND OF THE INVENTION The present invention relates to phosphinate based derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of arthritis,
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