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adriamycin/рак
Линкът е запазен в клипборда
Страница 1 от 35 резултата
Adriamycin esters, their preparation and use
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to novel adriamycin esters, a process for their preparation, and the uses thereof.
2. The Prior Art
U.S. Pat. No. 3,803,124, owned by the unrecorded assignee hereof, discloses the preparation of certain C-14
Treatment of bladder cancer to overcome chemoresistance
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BACKGROUND
Bladder cancer (BCa) is the second most prevalent and the most deadly urogenital cancer in men. In addition to the high recurrence rates, BCa is refractory to chemotherapy and is thus considered one of the most difficult to treat. Although an eradication of primary lesions by chemotherapy
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
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TECHNICAL FIELD OF THE INVENTION
The present invention relates to a novel method for the delivery of cytotoxic agents to tumor cells by the combined use of antibody-enzyme conjugates and prodrugs. More particularly, this invention relates to a method for the delivery of cytotoxic drugs to the site
C-glycosidic adriamycin analogs
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TECHNICAL FIELD
This invention concerns synthetic methods in the preparation of desired organic compounds. More particularly, the invention concerns general methods which can be used specifically for the preparation of intermediates in the synthesis of G-glycosidic adriamycin and ametantrone analogs
Antineoplastic enamine derivatives of daunorubicin and adriamycin
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BACKGROUND OF THE INVENTION
This invention concerns new enamine derivatives of daunorubicin and adriamycin having the general formula 1 and 2, wherein R denotes a hydrogen atom or a hydroxyl group. The inventive derivatives are usefyl antineoplastic antibiotics utilized in the treatment of cancer,
Conjugates of proteins with anti-tumor agents
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This invention relates to conjugates of proteins with anti-tumor agents, and more particularly to conjugates of transferrin or ceruloplasmin with anti-tumour agents. The invention also relates to methods for preparing such conjugates.
Transferrin is a protein which occurs in blood plasma, including
Conjugates of apotransferrin proteins with anti-tumor agents
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There are now described, by way of example, conjugates of transferrin and ceruloplasmin according to the present invention, and a method for preparing the same, with reference to the accompanying drawings, in which:
FIG. 1a shows the results of gel filtration chromatography of native
Pharmaceutical preparations for inhibiting tumours associated with prostate adenocarcinoma
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FIELD OF THE INVENTION
The present invention relates to pharmaceutical preparations for use as tumour suppressive agents for tumours arising from prostatic adenocarcinoma, stomach cancer, breast cancer and benign prostatic hyperplasia.
BACKGROUND OF THE INVENTION
The prostate gland, which is found
Pharmaceutical preparations and methods for inhibiting tumors
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FIELD OF THE INVENTION
The present invention relates to pharmaceutical preparations (i.e., composition) for use as tumor suppressive agents for tumors arising from cancers such as prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial and ovarian cancers, and benign prostate
Pharmaceutical preparations and methods for inhibiting tumors
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FIELD OF THE INVENTION
The present invention relates to pharmaceutical preparations (i.e., composition) for use as tumor suppressive agents for tumors arising from cancers such as prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial and ovarian cancers, and benign prostate
Pharmaceutical preparations and methods for inhibiting tumors
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FIELD OF THE INVENTION
The present invention relates to pharmaceutical preparations (i.e., composition) for use as tumor suppressive agents for tumors arising from cancers such as prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial and ovarian cancers, and benign prostate
Treatment of carcinomas using squalamine in combination with other anti-cancer agents
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BACKGROUND OF THE INVENTION
I. Information Relating to Previous Squalamine Applications
This invention relates to various methods for using squalamine. Squalamine, having the structure illustrated in FIG. 1, is an aminosterol which has been isolated from the liver of the dogfish shark, Squalus
Conjugate of adriamycin and cyclodextrin
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This invention relates to novel adriamycin derivatives, and more specifically to a conjugate of adriamycin and cyclodextrin having less side effects and good durability of a blood level and exhibiting excellent therapeutic effects.
Daumomycin (see U.S. Pat. No. 3,616,242) and adriamycin (see U.S.
N-Acetyl-cysteine protects against cardiac damage from subsequently-administered cardio-toxic anthra-cycline in cancer therapy
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This invention relates to N-acetyl-cysteine having the formula ##STR1## and has as its object the use of this compound to block cardiac damage resulting from the use of anthracyclines, notably adriamycin, in cancer therapy.
The anthracyclines have the general formula ##STR2## and their essential
Open chain-morpholino adriamycins
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TECHNICAL FIELD
The invention relates to providing compounds useful in chemotherapeutic treatment of tumors. In particular, it relates to analogs of doxorubicin and daunorubicin useful as chemotherapeutic agents.
BACKGROUND ART
A wide variety of anti-metabolites and other compounds have been used in
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