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7 резултата
A comparison between skin-photosensitizing (344 nm) activities of 8-methoxypsoralen and angelicin.
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8-methoxypsoralen and angelicin, locally applied to the skin of the rabbit, photosensitized erythema under UV irradiation to an approximately equal extent. Incident UV irradiation was restricted mainly to 334 nm. This indicates that furocoumarin-DNA cross-links are not important in erythema
Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin.
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Investigations on light reactions in a patient with vitiligo are presented. The minimal erythema dose (MED) in the UVB area was approximately 1/3 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300-310 nm. Action spectrum studies
Phytophotodermatitis in Rijeka region, Croatia.
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Contact with plants can cause phototoxic or rarely photoallergic reactions. Phototoxic dermatitis (photophytodermatitis) occurs after contact or ingestion of plants containing furocumarins i.e. psoralens and followed by sun exposure. Skin lesions develop usually after 24-48 hours with erythema,
Furocoumarin sensitization induces DNA-protein cross-links.
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The capacity of some linear and angular furocoumarins to induce DNA-protein cross-links by UVA (320-400 nm) irradiation has been evaluated in Chinese hamster ovary cells. Two linear furocoumarins, psoralen and 8-methoxypsoralen appeared to be capable of inducing DNA-protein cross-links to a
Present aspects concerning the molecular mechanisms of photochemotherapy with psoralens.
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The various photophysical and photochemical events that can be produced by psoralens after their excitation by UV-A radiation are reviewed, with particular reference to their possible significance for induction of photobiological effects. A close correlation has been found between the covalent
4'-Methylangelicin derivatives: a new group of highly photosensitizing monofunctional furocoumarins.
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The photobiological properties of three new angelicin derivatives carrying a methyl-group in 4' position at the furanic ring have been studied. In double-irradiation experiments on E. coli cells, they appeared to behave as monofunctional reactives towards DNA, similarly to the other angelicin
Production of active oxygen species (1O2 and O2-.) by psoralens and ultraviolet radiation (320-400 nm).
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Furocoumarins (psoralens) are potent skin photosensitizing agents that are used in combination with long-wavelength ultraviolet radiation (320-400 nm) in the treatment of psoriasis and other skin diseases. Twelve linear and angular psoralens, capable of forming monofunctional and bifunctional
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