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Structure-based discovery of caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility.

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Febrile seizures (FS), the most common seizures in childhood and often accompanied by later epileptogenesis, are not well controlled. Inflammatory processes have been implicated in the pathophysiology of epilepsy. However, whether the caspase-1 (Casp1) is involved in FS generation and

Seizures activated by therapeutic levels of lithium carbonate.

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We have described a 22-year-old woman who manifested clinical seizures after treatment with lithium carbonate was initiated. Serial electroencephalograms showed both nonspecific activation and activation of an epileptiform discharge with serum levels of lithium carbonate maintained within the

Therapeutic hypothermia for refractory status epilepticus in a child with malignant migrating partial seizures of infancy and SCN1A mutation: a case report.

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Status epilepticus (SE) is a common indication for neurocritical care and can be refractory to standard measures. Refractory SE (RSE) is associated with high morbidity and mortality. Unconventional therapies may be utilized in certain cases, including therapeutic hypothermia (TH), bumetanide, and

Seizure Induced by a Therapeutic Dose of Venlafaxine ER: A Case Report.

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Venlafaxine is a selective serotonin and norepinephrine reuptake inhibitor commonly used for the treatment of depression. Although listed as an adverse reaction, seizure activity associated with a therapeutic dose of venlafaxine has rarely been documented. A review of the literature reveals only 2

Provision of Sedation and Treatment of Seizures During Neonatal Therapeutic Hypothermia

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Hypoxic-ischemic encephalopathy (HIE) produces a high rate of long-term neurodevelopmental disability in survivors. Therapeutic hypothermia dramatically improves the incidence of intact survival, but does not eliminate adverse outcomes. The ideal provision of sedation and treatment of seizures

[Diagnostic and therapeutic aspects of the initial epileptic seizure].

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We present the concept of an 'epileptic syndrome' which is important for prognostic statements and the application of appropriate therapeutic measures. We then discuss the epileptic seizure and the assessment of suspected seizure, indications for admission to a hospital, diagnostic measures (EEG, CT

Seizures associated with therapeutic doses of venlafaxine and trimipramine.

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OBJECTIVE To report a patient having a first-time seizure after receiving venlafaxine and trimipramine for depression. METHODS A 25-year-old white woman with chronic depression was treated with venlafaxine 150 mg/d and trimipramine 50 mg/d. Eleven days after increase of the trimipramine dosage to

Anticonvulsant effects of magnesium sulfate on hippocampal seizures: therapeutic implications in preeclampsia-eclampsia.

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OBJECTIVE The objective of this study was to determine whether magnesium sulfate has central anticonvulsant effects. METHODS In three experiments we investigated the anticonvulsant properties of magnesium sulfate on the hippocampus because of its high density of N-methyl-D-aspartate receptors and

Effectiveness of a therapeutic drug monitoring service as an aid to the control of canine seizures.

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The results presented were derived from an anticonvulsant monitoring service, provided for two years to practising veterinary surgeons, in which samples of serum were taken from dogs treated with either primidone or phenobarbitone. Of the 19 patients assessed, 13 were controlled after the

Are Ketamine Infusions a Viable Therapeutic Option for Refractory Neonatal Seizures?

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Ketamine is an N-methyl-d-aspartate (NMDA) receptor antagonist that works by binding to the phencyclidine-binding site, thereby blocking influx of cations through the NMDA receptor channel. The use of ketamine to treat refractory status epilepticus in adults and older children is well documented.

Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia.

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An 82-year-old man treated with phenytoin for the prevention of symptomatic epilepsy was hospitalized to treat consciousness disturbance, seizure, and hypocalcemia (serum calcium: 4.6 mg/dL). Serum 25-hydroxyvitamin D level was very low (5.4 ng/mL), whereas serum calcitriol level was normal (27

Decline in seizure propensity in seizure-free patients as reflected in the evolution of the therapeutic antiepileptic drug threshold.

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To better understand mechanisms of remission, the decline in seizure propensity in seizure-free patients was investigated. Plasma antiepileptic drug levels were measured in 199 adults seizure-free for 2 or more years, who consented to reduction and eventual discontinuation of therapy. Among 117

Prevention of recurrent febrile convulsions--a randomized therapeutic assay: sodium valproate, phenobarbital and placebo.

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The purpose of this study was to compare three different modes of treatment in the prevention of relapses of febrile convulsions (Phenobarbital = PH, Sodium Valproate = SV, Placebo = PO) in a randomized therapeutic trial. The patients included in the study had shown their first generalized

Propofol and methohexital as anesthetic agents for electroconvulsive therapy: a randomized, double-blind comparison of electroconvulsive therapy seizure quality, therapeutic efficacy, and cognitive performance.

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BACKGROUND Propofol is often used as an anesthetic agent for electroconvulsive therapy (ECT). Whether the relatively short seizure duration, resulting from the medication, deteriorates the seizure quality and therapeutic outcomes, or whether propofol might be associated with small but significant

Pyridoxine-dependent seizures, clinical and therapeutic aspects.

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Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of prenatal or neonatal onset, psychomotor retardation and death in untreated patients. Treatment requires life-long supplementation with pyridoxine (vitamin B6). The underlying defect is unknown, and

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