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13 резултата
Sulfonamide derivatives as D3-receptor ligands
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FIELD OF THE INVENTION
The present invention relates to new D.sub.3 dopamine receptor subtype selective ligands of formula (I) and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof which are useful in the therapy and/or prevention of
2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
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BACKGROUND OF THE INVENTION
Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the
2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
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Вход / Регистрация
BACKGROUND OF THE INVENTION
Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the
2-halo-5-alkynyl-pyridyl nicotinic ligands
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BACKGROUND OF THE INVENTION
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels in the central nervous system (CNS) and the peripheral nervous system (PNS). The nAChRs serve a wide range of physiological functions, and have been implicated in a number of pathological
2-halo-5-alkynyl-pyridyl nicotinic ligands
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Вход / Регистрация
BACKGROUND OF THE INVENTION
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels in the central nervous system (CNS) and the peripheral nervous system (PNS). The nAChRs serve a wide range of physiological functions, and have been implicated in a number of pathological
Phenyl-substituted nicotinic ligands, and methods of use thereof
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Вход / Регистрация
BACKGROUND OF THE INVENTION
Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the
Phenyl-substituted nicotinic ligands, and methods of use thereof
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Вход / Регистрация
BACKGROUND OF THE INVENTION
Neuronal nicotinic acetylcholine receptors (nAChRs) serve a wide range of physiological functions and have been implicated in a number of pathological processes and pharmacological effects of nicotinic drugs. Many of the important in vivo effects of nicotine in the
Ligands for nicotinic acetylcholine receptors, and methods of making and using them
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BACKGROUND OF THE INVENTION
The endogenous cholinergic neurotransmitter, acetylcholine, exert its biological effect via two types of cholinergic receptors; the muscarinic ACh receptors and the nicotinic ACh receptors. As it is well established that muscarinic ACh receptors dominate quantitatively
Urea and amide derivatives of aminoalkylpiperazines and use thereof
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TECHNICAL FIELD
The present disclosure relates to certain amides and ureas derived from aminobutyl piperazines. Compounds of the present disclosure are dopamine D3 receptor preferring antagonist or partial agonist ligands. Compounds of the present disclosure are useful as treatment agents for
Urea and amide derivatives of aminoalkylpiperazines and use thereof
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Вход / Регистрация
TECHNICAL FIELD
The present disclosure relates to certain amides and ureas derived from aminobutyl piperazines. Compounds of the present disclosure are dopamine D3 receptor preferring antagonist or partial agonist ligands. Compounds of the present disclosure are useful as treatment agents for CNS
Methods for treating vascular dementia
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FIELD OF THE INVENTION
The invention describes novel methods for treating and preventing dementia caused by vascular diseases; dementia associated with Parkinson's disease; Lewy Body dementia; AIDS dementia; mild cognitive impairments; age-associated memory impairments; cognitive impairments and/or
Methods for treating dementia due to HIV disease
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FIELD OF THE INVENTION
The invention describes novel methods for treating and preventing dementia caused by vascular diseases; dementia associated with Parkinson's disease; Lewy Body dementia; AIDS dementia; mild cognitive impairments; age-associated memory impairments; cognitive impairments and/or
Methods for treating cognitive impairments or dementia
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FIELD OF THE INVENTION
The invention describes novel methods for treating and preventing dementia caused by vascular diseases; dementia associated with Parkinson's disease; Lewy Body dementia; AIDS dementia; mild cognitive impairments; age-associated memory impairments; cognitive impairments and/or
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