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carboxylic acid/некроза
Линкът е запазен в клипборда
8 резултата
Interleukin-1 and tumor necrosis factors-.alpha. modulators, syntheses of said modulators and methods of using modulators
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Вход / Регистрация
FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
Compounds as inhibitor of tumor necrosis factor alpha release
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BACKGROUND OF THE INVENTION
Release of such cytokines as tumor necrosis factor a (TNF-.alpha.) and transforming growth factor .alpha. (TGF-.alpha.) can cause adverse reactions ranging from psoriasis to sepsis. Many of these reactions are related to inflammation or autoimmune conditions, such as
Interleukin-1 and tumor necrosis factor-.alpha. modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
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Вход / Регистрация
FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
Interleukin-1 and tumor necrosis factor-.alpha. modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
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Вход / Регистрация
FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
Process for the preparation of O-substituted derivatives of (+)-cyanidan-3-01
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Вход / Регистрация
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol, especially 3-O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the formula I ##STR2## in which R represents an optionally substituted hydrocarbon radical; an acyl radical of an organic
3-O-acylated derivatives of (+)-cyanidan-3-ol
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Вход / Регистрация
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol, especially 3-O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the formula I ##STR2## in which R represents an optionally substituted hydrocarbon radical; an acyl radical of an organic
Metalloproteinase inhibitors
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Вход / Регистрация
This is a continuation-in-part of International Application PCT/GB95/00111, with an international filing date of Jan. 20, 1995.
The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions
Metalloproteinase inhibitors
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Вход / Регистрация
The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to the use of such compounds in medicine. In particular, the compounds are inhibitors of metalloproteinases
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