coronavirus infections/tyrosine

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The Safety & Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia

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As the coronavirus disease (COVID-19) spreads worldwide, awaiting the development of a vaccine, researchers are looking among the arsenal of available drugs, for a potential cure or medication to improve patients' outcome. A highly elevated levels of cytokines in COVID-19 patients requiring ICU

A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer

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Pathogenesis of BTK-mediated Hyper-Inflammatory Responses in COVID-19 (RESPOND)

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Coronavirus disease 2019 (COVID-19) is an acute respiratory syndrome caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Severe COVID-19 infection is associated with a hyper-inflammatory response and evidence of innate immune cell activation. Bruton tyrosine

sFlt1: a Biomarker of Organ Dysfunction in Critically-ill Patients With COVID-19?

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Extended description of the protocol, including more technical information (as compared to the Brief Summary) if desired. Do not include the entire protocol; do not duplicate information recorded in other data elements, such as eligibility criteria or outcome measures. (Limit : 32 000

Trial of Imatinib for Hospitalized Adults With COVID-19

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Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and at present with no approved or proven antiviral treatment. Imatinib is a tyrosine kinase inhibitor that has been approved for treatment of many

Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS

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This clinical trial is an open-label trial of ruxolitinib for the treatment of severe COVID-19 to assess its efficacy and safety. Ruxolitinib (INCB018424 phosphate, INC424, ruxolitinib phosphate) is a well established, potent and selective inhibitor of Janus kinase (JAK)1 and JAK2, with modest to

Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19

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Test plan overview Project phase Phase II Indication: Complementary treatment of COVID 19 The purpose of the study: Examine the efficacy and tolerance of a chlorine dioxide based preparation Study design: Quasi-experimental clinical case study Number of patients expected: 20 patients. Main inclusion

A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)

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A Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of BIIB091, a Bruton's Tyrosine Kinase (BTK) Inhibitor, in Healthy Adult Participants

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Initial protocol recruitment and follow up was completed by 10 Jan 2020 with an optional cohort intended for completion by April 2020. Subsequently, a decision was made not to progress this optional cohort in light of COVID-19 which has resulted in a delay in reporting the actual completion date.

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