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11 резултата
8-(biaryl)quinoline PDE4 inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to compounds that are substituted 8-(biaryl)quinolines. In particular, this invention is directed to substituted 8-(biaryl)quinolines which are phosphodiesterase-4 inhibitors wherein the biaryl group at the
Benzimidazolone derivatives as CB2 receptor ligands
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BACKGROUND OF THE INVENTION
This invention relates to benzimidazolone derivatives. These compounds have selective cannabinoid(CB)2 receptor binding activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the
Sulfonyl benzimidazole derivatives
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BACKGROUND OF THE INVENTION
This invention relates to sulfonyl benzimidazole derivatives. These compounds have selective cannabinoid (CB)2 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives
Compositions of novel opioid compounds and method of use thereof
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BACKGROUND OF THE INVENTION
1. Technical Field
This invention relates generally to diarylmethylpiperazine compounds useful as mu and/or delta receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug
Selective opioid compounds
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TECHNICAL FIELD
This invention relates to morphinan compounds useful as .mu., .kappa. and/or .delta. receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder
Selective opioid compounds
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TECHNICAL FIELD
This invention relates to morphinan compounds useful as .mu., .kappa. and/or .delta. receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder
Cannabinoid receptor modulators
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a National Stage Application under 35 U.S.C. .sctn.371 of International Application No. PCT/US2010/002360, filed Aug. 27, 2010, which claims priority under 35 U.S.C. .sctn.119(e) to U.S. Provisional Application Nos. 61/275,506, filed Aug.
Cannabinoid receptor modulators
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FIELD OF THE INVENTION
The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB.sub.2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions
Crystalline forms and processes for the preparation of cannabinoid receptor modulators
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FIELD OF THE INVENTION
The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclop- ropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that
Crystalline forms and processes for the preparation of cannabinoid receptor modulators
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FIELD OF THE INVENTION
The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclop- ropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that
Antitussives
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TECHNICAL FIELD
The present invention relates to antitussive application of octahydroisoquinoline derivatives.
BACKGROUND ART
Codeine known as a representative antitussive capable of securely stopping cough acts on opioid .mu. receptors to basically cause adverse effects such as drug dependence,
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