diabetic ketoacidosis/phosphatase

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[Changes of blood-cerebrospinal fluid barrier in rabbits with diabetic ketoacidosis].

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OBJECTIVE To explore the mechanism of the changes of blood-cerebrospinal fluid barrier in rabbits with diabetic ketoacidosis (DKA). METHODS The New Zealand rabbits were injected with 150 mg/kg streptozotion and alloxan monohydrate each (model group, n=6) intravenously, or equal volume of normal

[Serum enzyme alterations during diabetic ketoacidosis. Prospective study of the behaviour of AP, AsAT, AIAT, and GGPT in 24 cases (author's transl)].

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Because of the scarcity of data on the changes of serum enzymes during diabetic ketoacidosis, the authors have prospectively studied the alterations of gamma-glutamyl transpeptidase (GGTP), alkaline phosphatase (AP), aspartate aminotransferase (AsAT), and alanine aminotransferase (AIAT) in this

Bone calcium changes during diabetic ketoacidosis: a comparison with lactic acidosis due to volume depletion.

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In this study, we aimed to compare bone calcium system changes from children with diabetic ketoacidosis or acute metabolic acidosis due to dehydration to find out the relative contribution of metabolic acidosis and diabetes-related factors on expected negative calcium balance. We studied a set of

[Subclassification of seronegative type 1 diabetic subjects with HLA-DQ genotypes].

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OBJECTIVE To reveal the relationship between disease phenotype and HLA-DQ genotype in autoantibody-negative type 1 diabetics and to explore whether HLA-DQ genotypes can reclassify seronegative type 1 diabetic patients. METHODS Sixty-one diabetics with unprovoked ketosis or ketoacidosis at

Evaluation of nephrotoxicity with renal antigens in children: role of Tamm-Horsfall protein.

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Renal antigens are proteins that originate from the kidney and are detectable in urine by immunological techniques. After renal injury cell fragments are shed and appear in urine. Thus, the appearance of cellular fragments represents acute damage to renal cells caused by various means. With this

[Factors involved in ketoacidosis at the onset of type 1 diabetes in childhood].

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BACKGROUND In some patients the ketoacidosis at the onset of type 1 diabetes has been observed. OBJECTIVE The aim of this study was to investigate an effect of the clinical, genetic, immunological and metabolic parameters on the occurrence of ketoacidosis at the clinical onset of the

[Use of ABC typing to redefine subtypes of acute-onset type 1 diabetes mellitus: study of 308 patients].

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OBJECTIVE To investigate the feasibility of ABC typing to redefine the subtypes of acute-onset type 1 diabetes mellitus (DM). METHODS Radioligand assay was used to detect glutamic acid decarboxylase-antibody (GAD-Ab) and tyrosine phosphatase autoantibody (IA-2A) in 308 patients with acute-onset type

Diabetes mellitus-associated glycogen storage hepatomegaly: report of a case and review of the Japanese literature.

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A huge hepatomegaly was seen in a 30-yr-old female diabetic who was treated with high dose of insulin for her uncontrollable food ingestion. The liver function at the peak of the hepatic enlargement showed a moderate increase of transaminases, alkaline phosphatase, and gamma-glutamyl transpeptidase.

Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.

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OBJECTIVE Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the intracellular domain of IA-2. Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic

The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes.

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BACKGROUND The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type

Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus--a nationwide study.

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OBJECTIVE To test the hypothesis that there is lower prevalence of islet antibodies in subjects with newly diagnosed Type 1 diabetes mellitus in young adulthood than in children is associated with less severe diabetes at time of diagnosis. METHODS This investigation was based on a nationwide study

Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

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Here we report a case where the manifestations of insulin-dependent diabetes occurred following SARS-CoV-2 infection in a young individual in the absence of autoantibodies typical for type 1 diabetes mellitus. Specifically, a 19-year-old white male presented at our emergency department with diabetic

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