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Methods of use for a natural Thomsen-Friedenreich disaccharide compound

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TECHNICAL FIELD The invention relates to a Thomsen-Friedenreich disaccharide-containing glycopeptide purified from cod fish of approximately 100 kDa (designated TFD.sub.100) and methods of using the same in the suppression of cancer metastasis. BACKGROUND OF INVENTION Prostate cancer (PCa) is a

Screening test for early detection of colorectal cancer

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FIELD OF THE INVENTION This invention relates to a simple screening test for colorectal cancer whereby a marker is detected in rectal mucus. More particularly, this marker is detected in the mucus deposited on a support using Schiff's reagent. BACKGROUND OF THE INVENTION Colorectal carcinoma is the

Screening test for large intestinal cancer

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DESCRIPTION OF THE INVENTION 1. Technical Field of the Invention This invention relates to a screening test for large intestinal cancer by detecting the presence of the disaccharide .beta.-D-Gal-(1->>3)-D-GalNAc in large intestinal mucus. 2. Background Art Cancer of the colon, cecum, and

Synthetic glycoamines and methods for their use that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis

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FIELD OF THE INVENTION The present invention relates to pharmaceuticals that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis both in vitro and in vivo. Background of the Invention Cell adhesion is one important property that differentiates multi-cellular organisms from

Anti-cancer therapeutic compounds

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CROSS-REFERENCE TO RELATED APPLICATIONS This Application claims priority from U.S. patent application Ser. No. 09/495,723, filed on Feb. 1, 2000, which is a divisional of U.S. patent application Ser. No. 08/486,127, filed on Jun. 7, 1995 and now issued as U.S. Pat. No. 6,020,323, on Feb. 1, 2000,

Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use

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The present invention relates to specific glucosamine disaccharides, in particular to 2-N- and/or 2'-N-acylated glucosamine disaccharides, wherein at least one of the acyl groups is branched, and to compounds comprising these disaccharides. The present invention relates further to methods for

Disaccharide ligands for selectins

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This is the U.S. national stage entry under 35 U.S.C. .sctn. 371 of PCT/GB94/00088, filed Jan. 19, 1994. FIELD OF THE INVENTION This invention relates to a series of carbohydrate-based compounds which are useful as anti-inflammatory agents and as agents for the control of tumour metastasis, to the

Method of treating angiogenesis

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Growth factors comprise a family of polypeptides with a manyfold of properties regulating for example cell proliferation and cell metabolism. As being multi-functional molecules, they may stimulate or inhibit cell proliferation as well as affect cell function depending on the type of the target

Synthetic lipid-a-analogs and uses thereof

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FIELD OF THE INVENTION The present invention relates to novel synthetic structural mimics of bacterial Lipid-A and methods of synthesis of such analogs. Bacterial Lipid-A compositions are being widely used as adjuvant to enhance the immune responses to various antigens used in vaccine formulations.

Fullerene derivative and composition comprising the same

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TECHNICAL FIELD The present invention relates to fullerene derivatives, particularly, fullerene derivatives monosubstituted or disubstituted with monosaccharide or disaccharide residues via an alkylene group or their salts, a method of producing the same and compositions for photosensitization

Composition for macrophage activation

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FIELD OF THE INVENTION The present invention provides novel lipophilic disaccharide-tripeptide compounds having improved immunological efficacy, and a liposome encapsulated composition comprising said compounds. BACKGROUND OF THE INVENTION Intact microbial agents are known to have immunological

Alpha-selective sialyl phosphate donors for preparation of sialosides and sialoside arrays for influenza virus detection

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TECHNICAL FIELD OF THE INVENTION The invention generally relates to the synthesis of sialosides. In particular, the invention relates to synthesis of disialides using novel sialyl phosphate donor compounds. Specifically, the invention relates to synthesis of polysialic acids using novel sialyl

Compositions and methods for regulation of active TNF-.alpha.

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1. FIELD OF THE INVENTION The present invention relates to substances, their compositions, and methods for the regulation of cytokine activity, for instance, the up regulation or down regulation of Tumor Necrosis Factor alpha (TNF-.alpha.) activity. In particular, substances and pharmaceutically

Methods for regulation of active TNF-.alpha.

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Saccharide conjugates

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FIELD OF THE INVENTION This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. BACKGROUND OF THE INVENTION The bleomycins (BLMs) are a family of glycopeptide-derived antitumor antibiotics

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