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5 резултата
[New findings on the efficacy and mode of action of the horse chestnut saponin escin].
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In order to complete previous results of the efficacy of the horse chestnut saponin escin, its activity was tested on two further models of inflammation: the rat serous peritonitis provoked by i.p. injection of formalin solution, and the rat serous pleurisy provoked by intrapleural injection of
Influence of alpha-escin on skeletal changes in ovariectomized rats.
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The aim of the present study is to investigate the influence of alpha-escin (35 mg/kg per os daily; administered for 4 weeks) on the development of osteopenia caused by bilateral ovariectomy in 3-month-old female Wistar rats. The experiments were carried out on four groups of animals: I (C)--control
Effects of alpha-escin on histomorphometrical parameters of long bones in rats with experimental post-steroid osteopenia.
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The excess of glucocorticosteroids leads to the development of osteopenia. A decreased bone formation rate and an increased bone resorption rate are observed. The aim of the present study was to investigate the effects of alpha-escin on the experimental prednisolone-induced osteopenia. The
Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide
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Due to fast nasal mucociliary clearance, only the dissolved drug content can effectively permeate the mucosa and be pharmaceutically active after intranasal application of suspensions. Therefore, the aim of this study was to increase the budesonide concentration in solution of a nasal spray
Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract.
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Horse chestnut extract (HCE), containing 70% escin, is the main active component of Veinotonyl 75. The aim of this work was to investigate pharmacological properties attempting to elucidate the efficacy of HCE in chronic venous insufficiency. Veinotonic and lymphagogue properties: HCE dose
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