febrile neutropenia/епилептични припадъци

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Outcomes of a clinical pathway for primary outpatient management of pediatric patients with low-risk febrile neutropenia.

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Fever and neutropenia is a common reason for nonelective hospitalization of pediatric oncology patients. Herein we report nearly five years of experience with a clinical pathway designed to guide outpatient management for patients who had low-risk

Febrile neutropenia and hemorrhagic stroke in a thalassemia major patient.

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A 36-year-old transfusion-dependent thalassemia major patient presented with febrile neutropenia and anemia. Deferiprone (L1) was discontinued as it was suspected to be the offending agent and prompt broad-spectrum antibiotic therapy was initiated after which the patient improved. After 11 days the

[A phase III study of the efficacy and safety of meropenem in patients with febrile neutropenia].

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Efficacy, safety and pharmacokinetics of meropenem (MEPM) were assessed when 1 g (40 mg/kg for some of the pediatric patients) t.i.d. was administered every 8hours to 101 adult and 6 pediatric patients with febrile neutropenia (FN) as diagnosed based on the Japanese guideline for FN treatment. The

Fatal Clostridium septicum febrile neutropenia during adjuvant chemotherapy for early breast cancer

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We report the case of a 76-year-old female patient with early breast cancer (hormone receptor-positive erbb2 amplified) that had started adjuvant chemotherapy with docetaxel, carboplatin and trastuzumab (TCH). Eight days after the first cycle of TCH chemotherapy, the patient was diagnosed with grade

Common complications and emergencies associated with cancer and its therapy.

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BACKGROUND As the incidence of cancer rises and as physicians treat it more aggressively, more patients will experience complications of cancer or of its therapy. OBJECTIVE To review the pathogenesis, diagnosis, and treatment of the superior vena cava syndrome, malignant pericardial effusions, the

Cefepime neurotoxicity despite renal adjusted dosing.

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Neurotoxicity is a rare side-effect of cefepime. There are previous reports of cefepime neurotoxicity in patients whose dosages were not adjusted for their kidney disease. We report a toxic case of non-convulsive status epilepticus in a patient receiving renally-dosed cefepime. A 70-y-old woman was

Assessment of an alternative meropenem dosing strategy compared with imipenem-cilastatin or traditional meropenem dosing after cefepime failure or intolerance in adults with neutropenic fever.

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OBJECTIVE To compare clinical outcomes of patients receiving an alternative dosage of meropenem with those of patients receiving imipenem-cilastatin or the traditional dosage of meropenem after failure of or intolerance to cefepime for treatment of febrile neutropenia. METHODS Retrospective,

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study.

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Treatment failure from drug resistance is the primary reason for relapse in acute lymphoblastic leukemia. Improving outcomes by targeting mechanisms of drug resistance is a potential solution.We report results investigating the epigenetic modulators

Meropenem -valproic acid interaction in patients with cefepime-associated status epilepticus.

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OBJECTIVE Two case reports of rapid decreases in valproic acid levels after initiation of meropenem in patients who developed new-onset seizure activity during treatment with cefepime are presented. CONCLUSIONS A 60-year-old Caucasian woman with myelodysplasia was transferred to the medical

A Review of Clinical Outcomes Associated with Two Meropenem Dosing Strategies.

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Meropenem is a carbapenem antibiotic that exhibits time-dependent bactericidal activity, traditionally dosed intravenously at 1 g every 8 h. In order to maximize its pharmacodynamic activity and reduce costs, an alternative regimen employed by many institutions is 500 mg every 6 h. The objective of

Overdose of lomustine: report of two cases.

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Two male patients with high-grade gliomas were treated with subtotal or total resection and radiotherapy followed by a lomustine-containing chemotherapy regimen. Both patients took lomustine at an oral dose of 800 mg over five days instead of their regular doses of 200 and 240 mg. Grade 4

Evaluation of pediatric patients with an oncologic emergency: Single center experience.

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Çiftçi AÇ, Küpeli S, Sezgin G, Bayram İ. Evaluation of pediatric patients with an oncologic emergency: Single center experience. Turk J Pediatr 2018; 60: 660-668. In this study, we aimed to prospectively analyze the emergency diagnosis and clinical characteristics of the oncologic emergency patients

Meropenem versus ceftazidime as empirical monotherapy for febrile neutropenic cancer patients.

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A total of 101 cancer patients with 121 febrile neutropenia episodes were randomised to receive empirical treatment with i.v. meropenem (1g/8 h) or ceftazidime (2 g/8 h). After 3 days, 89% of patients were on unmodified therapy in the meropenem group, compared with 83% in the ceftazidime group. Of

A retrospective analysis of complications observed in children with acute lymphoblastic leukemia during chemotherapy.

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BACKGROUND We aimed to evaluate the complications that we observed in children with acute lymphoblastic leukemia (ALL) during the remission induction, consolidation, and reinduction phases of chemotherapy retrospectively. METHODS We analysed the clinical records of 128 patients with ALL who were

Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia.

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We describe an 18-year-old man with acute leukemia who presented with posterior reversible encephalopathy syndrome (PRES) shortly after developing acute pancreatitis. On day 15 after the third consolidation course with high-dose cytarabine, treatment with broad-spectrum antibiotics was initiated for

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