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A study on the antiviral action of a polyphenolic complex isolated from the medicinal plant Geranium sanguineum L. VIII. Inhibitory effect on the reproduction of herpes simplex virus type 1.

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The antiviral activity of a polyphenolic complex, isolated from a Bulgarian medicinal plant Geranium sanguineum L., on the reproduction of herpes simplex virus type 1 was studied. The substance inhibited the intracellular stages of viral replication and exhibited a virucidal effect.

In vitro antioxidant activity of polyphenol extracts with antiviral properties from Geranium sanguineum L.

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Recent evidence shows that plant polyphenols exhibit antioxidant and radical scavenging properties. By three separate and complementary methods--DPPH assay, beta-carotene-linoleic acid assay and NBT-reduction assay it was established that a polyphenol-rich extract from the medicinal plant Geranium

Combined effect of selected antiviral substances of natural and synthetic origin. II. Anti-influenza activity of a combination of a polyphenolic complex isolated from Geranium sanguineum L. and rimantadine in vivo.

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The synergistic effect shown by the combination of a natural product, polyphenolic complex (PC) isolated from Geranium sanguineum L., and rimantadine (R) in vitro and in ovo [7], encouraged us to continue these studies by in vivo testing. A marked protective effect in experimental influenza virus A

[Antiviral action of a polyphenol complex isolated from the medicinal plant Geranium sanguineum L. II. Its inactivating action on the influenza virus].

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[Antiviral effect of a polyphenolic complex isolated from the medicinal plant Geranium sanguineum L. V. Mechanism of the anti-influenzal effect in vitro].

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[Antiviral action of a polyphenol complex isolated from the medicinal plant Geranium sanguineum L. I. Its inhibiting action on the reproduction of the influenza virus].

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[The antiviral action of a polyphenol complex isolated from the medicinal plant Geranium sanguineum L. VI. Reproduction of the influenza virus pretreated with the polyphenol complex].

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[Combined action of antiviral substances of natural and synthetic origin. I. The anti-influenza action of a combination of the polyphenol complex isolated from Geranium sanguineum L. and remantadine in vitro and in ovo].

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Biologically active constituents of a polyphenol extract from Geranium sanguineum L. with anti-influenza activity.

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From the aerial roots of the medicinal plant Geranium sanguineum L. a polyphenol-rich extract with strong anti-influenza activity has been isolated. To investigate its active fractions, the extract was partitioned by solvents with increasing polarity. The n-BuOH fraction contained the majority of

Inhibition of influenza virus protein synthesis by a plant preparation from Geranium sanguineum L.

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A polyphenolic complex (PC) with antiviral properties has been isolated from the Bulgarian medicinal plant Geranium sanguineum L. A study was undertaken to investigate the effect of PC on virus-specific protein synthesis in influenza virus-infected cells. The expression of viral glycoproteins on the

In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.

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A polyphenolic complex (PC), isolated from the Bulgarian medicinal plant Geranium sanguineum L., was shown to have selective anti-influenza activity in vitro. Expression of HA on the surface of cells infected with A/chicken/Rostock/34, virus-induced cytopathic effect, infectious virus yield and

Antiherpes virus activity of extracts from the medicinal plant Geranium sanguineum L.

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The herpes virus inhibitory effect of five extracts from the Bulgarian medicinal plant Geranium sanguineum L. (Geraniaceae) was investigated. The water extract (WE) from the aerial roots of the plant was the least toxic for cell cultures and inhibited significantly the replication of herpes simplex

In vitro investigation on the effect of a plant preparation with antiviral activity on the functions of mice phagocyte cells.

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A polyphenol extract from the aerial roots of the medicinal plant Geranium sanguineum L. (PC) inhibited the reproduction of influenza viruses type A and B in vitro and in ovo and protected mice from mortality in the experimental influenza infection. The in vivo protective effect was connected with

Effect of a plant polyphenol-rich extract on the lung protease activities of influenza-virus-infected mice.

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Influenza infection was induced in white mice by intranasal inoculation of the virus A/Aichi/2/68 (H3N2). The lung protease and the protease-inhibitory activities were followed for 9 days after infection. The intranasal application of a polyphenol-rich extract (PC) isolated from Geranium sanguineum

Synergistic inhibition of influenza A virus replication by a plant polyphenol-rich extract and epsilon-aminocaproic acid in vitro and in vivo.

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A combined antiviral effect of a polyphenol-rich extract of the medicinal plant Geranium sanguineum L. (PC) and a protease inhibitor, epsilon-aminocaproic acid (ACA) was examined in Influenza A virus (IAV)-infected MDCK cell cultures and mice. Synergistic, antagonistic, or indifferent antiviral

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