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Страница 1 от 39 резултата
Methods, assays and kits for cancer diagnosis and screening utilizing glycan-binding and glycan epitopes
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FIELD OF THE INVENTION
The invention relates to the diagnosis, monitoring, prognosis, and/or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are
Prostate cancer glycan markers and autoantibody signatures
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REFERENCE TO SEQUENCE LISTING, COMPUTER PROGRAM, OR COMPACT DISK
None
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the fields of glycan biomarkers and serum anti-glycan antibody signatures of prostate disease.
2. Related Art
Presented below is background
Glycans as functional cancer targets and antibodies thereto
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CROSS-REFERENCE TO RELATED APPLICATIONS
This is the U.S. National Stage of International Application No. PCT/GB2014/053240, filed Oct. 31, 2014, which was published in English under PCT Article 21(2), which in turn claims the benefit of GB Patent Application No. 1319374.3, filed Nov. 1, 2013, which
O-glycan pathway ovarian cancer signature
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BACKGROUND
Ovarian cancer (OVCA) is the leading cause of gynecologic cancer mortality and the sixth most common cancer diagnosed in women in the United States. Advanced-stage epithelial OVCA is highly heterogeneous at a clinical, biologic, and genetic level, but patients are currently treated in a
Method of detecting cancer based on glycan biomarkers
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 3, 2014, is named 38075-720.201_SL.txt and is 15,023 bytes in size.
BACKGROUND OF THE
Glycan-interacting compounds
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REFERENCE TO THE SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jan. 20, 2016, is named 20331006USCON_SL.txt and is 4,229 bytes in
Glycan-interacting compounds
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REFERENCE TO THE SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copu, created on Nov. 22,2013, is named 20331066USCIP_SL.txt and is 4,289 bytes in
Glycan-interacting compounds and methods of use
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jan. 4, 2016, is named 20331012USCIP_SL.txt and is 144,844 bytes in size.
FIELD OF THE
Therapeutic method using fucose-containing proteoglycan or acidic glycan
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a class of proteoglycans having fucosylated acidic glycan side chains bound to a protein backbone which have been found to stimulate selectively proliferation of natural killer (NK) cells and/or .gamma..delta.T cells.
Fucose containing proteoglycan or acidic glycan and their pharmaceutical use
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
Not Applicable
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a class of proteoglycans having fucosylated acidic glycan side chains bound to a protein backbone which have been found to stimulate
Fucose containing proteoglycan or acidic glycan and their pharmaceutical use
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
Not Applicable
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a class of proteoglycans having fucosylated acidic glycan side chains bound to a protein backbone which have been found to stimulate
Method of targeting glycoproteins to treat cancer
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BACKGROUND
Field
The present disclosure relates to a method of treating cancer. More specifically, the present disclosure relates to the use of monoclonal antibodies for targeting truncated O-glycans on glycoproteins to inhibit activation of pro-survival cell signaling pathways. For example,
Compositions and methods for detecting cancer
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FIELD OF INVENTION
The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
BACKGROUND
Cancer is a leading cause of death worldwide, and mortality is
Lung cancer differential marker
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a national stage application filed under 35 USC .sctn.371 of PCT/JP2011/070635, filed Sep. 9, 2011, which claims the benefit of Japanese Patent Application No. 2010-209932, filed Sep. 17, 2010, both of which are incorporated by reference
Lung cancer differential marker
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SUBMISSION OF SEQUENCE LISTING
The Sequence Listing associated with this application is filed in electronic format via EFS-Web and hereby incorporated by reference into the specification in its entirety. The name of the text file containing the Sequence Listing is 119244_00124_Sequence_Listing. The
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