Patients will receive standard of care behavior and nutritional interventions. They will not receive cyproheptadine.

Patients will receive standard of care behavior and nutritional interventions. They will receive cyproheptadine every day for a total of two months. Standard dose of 0.25 mg/kg divided BID will be used.

Patients will receive standard of care behavior and nutritional interventions. They will receive cyproheptadine every day for two weeks cycled with no cyproheptadine given for two weeks for a total of two months. Patients on cycled dosing will be given cyproheptadine for two weeks, then no medication for two weeks; repeating this cycle for the two month duration of study

No Cyproheptadine Treatment

Patients will receive standard of care behavior and nutritional interventions. They will receive cyproheptadine every day for a total of two months. Standard dose of 0.25 mg/kg divided BID will be used.
Cyproheptadine

Continuous Cyproheptadine

Patients will receive standard of care behavior and nutritional interventions. They will receive cyproheptadine every day for two weeks cycled with no cyproheptadine given for two weeks for a total of two months. Patients on cycled dosing will be given cyproheptadine for two weeks, then no medication for two weeks; repeating this cycle for the two month duration of study
Cyproheptadine

Cycled Cyproheptadine

Total

Sex: Female, Male

Region of Enrollment

Participants' guardians will complete the Mealtime Behavior Questionnaire (MBQ). This is a validated, 31-item, parent-report questionnaire assessing the mealtime behavior structure in young children above 2 years. The questionnaire measures variables including: 1) food refusals/avoidance; 2) food manipulation; 3) mealtime aggression and 4) choking/gagging/vomiting related to meals. Each behavior is assigned a frequency scale with 1 corresponding to "never" and 5 corresponding to "always." The MBQ then consist of a total score and four subcategory scores (listed above).

Feeding Behavior Questionnaire

Change in skin fold thickness as measured by centimeters and z-score percentiles

Anthropometrics: Skin Fold Thickness

Change in mid-arm circumference as measure by centimeters and z-score percentiles

Anthropometrics: Mid-arm Circumference

Change in BMI as measured by kilograms divided by meters squared and z-score percentiles

Anthropometrics: BMI

Change in height as measured in centimeters and z-score percentiles

Anthropometrics: Height

Change in weight as measured in kilograms and z-score percentiles

Anthropometrics: Weight

Patients will answer affirmative or negative to a descriptive list of side effects commonly experienced when taking cyproheptadine. Examples of these descriptive variables include nausea, emesis, etc. Percentage of patients experiencing each side effect will be calculated and compared across the course of study.

Percentage of Participants Experiencing Side Effects From Cyproheptadine

Change in calorie intake will be recorded

24 Hour Diet Recall

Overall Study

Praveen Goday

Feeding Behaviors

Cyproheptadine

Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders

Professor of Pediatric Gastroenterology

Medical College of Wisconsin

Seizure

Patients newly prescribed PPI and H2RA, respectively

histamine/епилептични припадъци

Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders

Acid Suppressing Drug Seizure Epidemiology Study

Най-пълната база данни за лечебни билки, подкрепена от науката