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Phase II study of lonidamine in patients with metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group Study.

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The National Cancer Institute of Canada Clinical Trials Group conducted a phase II study of lonidamine, given in an escalating oral daily schedule to a maximum dose of 450 mg/m2 in patients with previously treated advanced breast cancer. Five responses were seen in 30 evaluable patients (17%).

[Neurological disturbances in post-surgical patients with breast cancer].

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OBJECTIVE to explore the sensory disturbances in the arm on the side of operation compared to the opposite upper extremity and evaluate quality of life in patients with breast cancer with postmastectomy syndrome. METHODS Authors examined 110 women during one year including 64 (58.2%) with intact

Sensory profiles in women with neuropathic pain after breast cancer surgery

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Purpose: We performed a detailed analysis of sensory function in patients with chronic post-surgical neuropathic pain (NP) after breast cancer treatments by quantitative sensory testing (QST) with DFNS (German Research Network on

Serratus Plane Block for Persistent Pain after Partial Mastectomy and Axillary Node Dissection.

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Persistent pain after breast cancer surgery (PPBCS) is defined as chronic neuropathic pain that persists for more than 3 months after surgery. The pain can be sufficiently severe to cause long-term disabilities and interfere with sleep and daily life. Serratus plane block (SPB) is a novel,

Phase I toxicologic study of Lonidamine in cancer patients.

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15 patients with metastatic cancer were treated with Lonidamine, a substituted indazole carboxylic acid active against the Lewis lung and Sarcoma 180 tumors. Single doses of 600 mg (350-400 mg/m2) mostly induced somnolence and gastro-intestinal side effects. Toxicity occurring during chronic

Phase II study of Lonidamine in cancer patients.

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12 patients with metastatic cancer were treated with the substituted indazole carboxylic acid Lonidamine at oral daily doses of 270 mg/m2. Toxicity, consisting mainly of myalgias, somnolence, hyperesthesia, anorexia and vomiting, generally decreased or disappeared over time despite continuing drug

Predictors of Persistent Neuropathic Pain--A Systematic Review.

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BACKGROUND Characterization of the prognostic variables for persistent neuropathic pain (PNP) remains incomplete despite multiple articles addressing this topic. To provide more insight into the recovery and prognosis of neuropathic pain, high-quality data are required that provide information about

Capsaicin in the Treatment of Refractory Neuropathic Pain after Mastectomy Surgery: A Case Report

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A 62-year-old female patient with a history of mastectomy surgery and sentinel lymphadenectomy in the context of breast cancer therapy was referred to our clinic for the treatment of refractory neuropathic pain. She reported a complex set of symptoms including burning and electrical-like sensations

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