hypopituitarism/triglyceride

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Risk factors of cardiovascular disease in GH-deficient adults with hypopituitarism: a preliminary report.

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BACKGROUND We estimated the influence of GH deficiency (GHD) in adults on chosen risk factors of cardiovascular disease and bone density. METHODS Fifty-four adults (mean age: 50.4 years) with hypopituitarism were studied. We measured blood pressure, body mass index, waist-to-hip ratio, total body

Effects of growth hormone treatment on very-low density lipoprotein apolipoprotein B100 turnover in adult hypopituitarism.

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Adult hypopituitarism is associated with hyperlipidemia, mainly due to an increase of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) levels. Recent studies have shown that such patients exhibit increased hepatic secretion of VLDL apolipoprotein B100 (VLDL apo B100). To examine

Correction of cortisol overreplacement ameliorates morbidities in patients with hypopituitarism: a pilot study.

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BACKGROUND Hypopituitarism in adults is known to be associated with deleterious effects on body composition, lipid profile and quality of life (QoL). This was attributed to GH deficiency. The potential role of glucocorticoid overreplacement had never been investigated. OBJECTIVE To investigate

Hyperlipidaemia in patients with hypopituitarism.

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Five patients with hypopituitarism due to Sheehan's syndrome showed hyperlipidaemia of various lipoprotein phenotypes. Postheparin plasma lipoprotein lipase activity was subnormal in 4 of the 5 patients and hepatic triglyceride lipase was markedly decreased in all patients studied. After

Decreased high density lipoprotein cholesterol in hypopituitarism.

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Serum triglyceride, cholesterol, and high density lipoprotein cholesterol (HDL-C) levels were measured in 10 men and 3 women with hypopituitarism. The mean total cholesterol and triglyceride levels were significantly increased but were within the range of controls. The mean HDL-C concentration and

Inflammatory cardiovascular risk markers in women with hypopituitarism.

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Patients with hypopituitarism have increased cardiovascular mortality. A high prevalence of conventional cardiovascular risk factors, including obesity, central fat distribution, insulin resistance, and dyslipidemia, have been described in these patients. The inflammatory markers C-reactive protein

Hypopituitarsim is associated with triglyceride enrichment of very low-density lipoprotein.

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The dyslipidemia associated with hypopituitarism may contribute to increased vascular mortality. The atherogenic potential of lipoproteins is determined not only by concentration but also by their composition. We therefore studied very low-density lipoprotein composition and apolipoprotein B

Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism.

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OBJECTIVE Hypopituitarism is associated with metabolic alterations but in TBI-induced hypopituitarism data are scanty. The aim of our study was to evaluate the prevalence of naïve hypertension, dyslipidemia, and altered glucose metabolism in TBI-induced hypopituitarism

Effect of long-term GH replacement therapy on cardiovascular outcomes in isolated GH deficiency compared with multiple pituitary hormone deficiencies: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults.

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OBJECTIVE Isolated GH deficiency (IGHD) could provide a model to investigate the influence of GH deficiency per se and the effect of GH replacement therapy without the influence from other pituitary hormone deficiencies or their treatment. The aim of this study is to address the questions about

[Changes in the lipid profile and thyroid function in adult patients with hypopituitarism after substitutive treatment with growth hormone].

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BACKGROUND Adult growth hormone (GH) deficiency is associated with changes in serum lipid levels that can modify after GH substitution. METHODS We studied 18 patients with GH deficiency treated with GH for 18 or 24 months. RESULTS A decrease of total cholesterol, LDL with an increase in HDL without

Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone.

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Increased mortality due to cardiovascular disease has been described in adult patients with untreated growth hormone (GH) deficiency. GH replacement therapy has been demonstrate to improve vascular reactivity and reverses early atherosclerotic changes in GH deficient adults. The objective of this

GH replacement in hypopituitarism improves lipid profile and quality of life independently of changes in obesity variables.

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OBJECTIVE GH deficiency (GHD) in adults is characterized by elevated body mass index (BMI), increased waist girth (WG) and increased fat mass (FM). Information about how these indicators of obesity affect the lipid profile and quality of life (QoL) of GHD subjects is scarce. It is also unclear how

Serum Lipid and Leptin Concentrations in Patients with Sheehan Syndrome.

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UNASSIGNED Sheehan syndrome (SS) refers to the occurrence of hypopituitarism after parturition. Hypopituitary adults with growth hormone (GH) deficiency have abnormal body composition with increased fat mass. As leptin is secreted almost exclusively by fat cells and the circulating leptin level is

Long-term follow-up results of growth hormone therapy for patients with adult growth hormone deficiency.

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OBJECTIVE We evaluated the long-term effects of growth hormone (GH) on markers of quality of life, glucose metabolism, and lipid metabolism to validate the adequacy of long-term GH replacement therapy for adult GH deficiency (AGHD). METHODS Eighty-three of 100 sequentially followed patients who

Effect of growth hormone (GH) on fasting and postprandial metabolism in GH deficiency.

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OBJECTIVE Hypopituitarism with adult-onset growth hormone deficiency (GHD) is associated with increased cardiovascular morbidity and mortality due to premature and progressive atherosclerosis. An underlying cause of atherosclerosis is increased insulin resistance. Elevated fasting and postprandial

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