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isocitrate dehydrogenase/рак

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Use of isocitrate dehydrogenase 1 as a diagnostic and prognostic biomarker and therapeutic target for lung cancers

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CROSS REFERENCE TO RELATED APPLICATIONS The present application is a U.S. National Phase of International Patent Application Serial No. PCT/CN2012/081327, entitled "ISOCITRATE DEHYDROGENASE 1 AS A DIAGNOSTIC AND PROGNOSTIC BIOMARKER AND THERAPEUTIC TARGET FOR LUNG CANCERS," filed on Sep. 13, 2012,

Use of isocitrate dehydrogenase 1 as a diagnostic and prognostic biomarker and therapeutic target for lung cancers

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INCORPORATION BY REFERENCE OF ELECTRONICALLY SUBMITTED MATERIAL Incorporated by reference in its entirety herein is a computer-readable nucleotide sequence listing submitted herewith and identified as follows: 3,201 bytes ASCII (Text) file named "Sequence_Listing_JEE15301PCTUSDIV," created Sep. 28,

Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors

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FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Phenyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors

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FIELD OF INVENTION The present invention is directed to inhibitors of mutant iso citrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers.

Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,

Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Вход / Регистрация
FIELD OF INVENTION The present invention is directed to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of diseases or disorders associated with such mutant IDH proteins including cell-proliferation disorders and cancers. Specifically,
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