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Surface modification of poly (l-lactic acid) microspheres for site-specific delivery of ketoprofen for chronic inflammatory disease.

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The purpose of this research was to investigate the potential of surface modified Poly (l-lactic acid) (PLA) microspheres as a carrier for site-specific delivery of anti-inflammatory drug, ketoprofen, for the treatment of rheumatoid arthritis. Microspheres were prepared by solvent evaporation method

The safety and efficacy of combining poly-L-lactic acid with intense pulsed light in facial rejuvenation: a retrospective study of 90 patients.

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BACKGROUND Poly-L-lactic acid (PLLA) is an effective treatment for panfacial volumization. Typically, patients who are candidates for volume restoration can benefit from lasers and light sources for photorejuvenation. OBJECTIVE To evaluate the safety and efficacy of combining PLLA with intense

Modified poly-L-lactic acid injection technique: safety and efficacy of "cross-fanning" in non-HIV-related facial atrophy.

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Proper injection of poly-l-lactic acid has a role in avoiding development of subcutaneous papules. We evaluated the safety and efficacy of our injection technique ("cross-fanning") and compared it to 4 previous studies. Forty patients were evaluated for adverse events (bruising, edema, erythema,

Understanding, avoiding, and treating potential adverse events following the use of injectable poly-L-lactic acid for facial and nonfacial volumization.

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Injection-related adverse events (AEs) may occur with the use of any injectable substance, including all commercially available fillers. The most common of these AEs include discomfort, bruising, edema, and erythema, which are generally transient and resolve spontaneously. The majority of AEs widely

The effect of bone marrow mesenchymal stem cell and nano-hydroxyapatite/collagen I/poly-L-lactic acid scaffold implantation on the treatment of avascular necrosis of the femoral head in rabbits.

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For avascular necrosis of the femoral head (ANFH), repair and regeneration are difficult because of the edema and high pressure caused by continuous ischemia and hypoxia. Core decompression (CD) is a classic method for treating early ANFH before the collapse of the femoral head; however, its effect

Evaluation of polyphosphates and polyphosphonates as degradable biomaterials.

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A series of polymers, bisphenol A-based poly(phosphoesters), were evaluated as degradable biomaterials. Degradation was observed for the four polymers studied under both in vitro and in vivo conditions. The rate of degradation was affected by polymer side-chain structure and correlated with the

Improving mandibular contour: A pilot study for indication of PPLA traction thread use.

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BACKGROUND The request for less-aggressive procedures to improve mandibular contour is increasing. Several kinds of threads have been used for this purpose. Nevertheless, PLLA (poly-L-Lactic acid) traction thread procedure has not been previously described. OBJECTIVE To investigate the role of PLLA

Long-term follow-up of anterior cervical discectomy and fusion with bioabsorbable plates and screws.

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OBJECTIVE Anterior cervical discectomy and fusion (ACDF) is an accepted technique for the management of cervical spinal degenerative disease. Recently, new resorbable materials have been proposed for the anterior cervical fusion to eliminate some of the disadvantages and complications of metal

[Massive heroin intoxication. Hemodynamic studies].

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Acute hemodynamic changes during heroin overdose have not been frequently reported. We observed 2 male patients aged 24 and 21 years admitted in coma and shock and presenting severe mixed acidosis, with, respectively, pH 6.80, PaCO2 72 mm Hg, PaO2 70 mm Hg, BE -18 mEq/l, lactic acid 16.5 mmol/l, and

Magnetic resonance imaging of bioabsorbale polylactic acid interference screws during the first 2 years after anterior cruciate ligament reconstruction.

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Bioabsorbable screws composed of poly(L-lactic acid) (PLA) were used for graft fixation and studied prospectively with serial magnetic resonance imaging (MRI) scans at 8, 16, and 24 months after autogenous patellar tendon anterior cruciate ligament (ACL) reconstruction in 10 patients. Conventional

Tolerance and pharmacokinetics of a ciprofloxacin-coated sinus stent in a preclinical model.

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Chronic rhinosinusitis (CRS) is often associated with persistent bacterial infection despite the use of systemic antibiotics. Topically administered antibiotics are an alternative strategy, but require effective local concentrations, prolonged mucosal contact time, minor systemic absorption, and

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