laryngeal neoplasms/phosphatase

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DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.

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DJ-1, a novel mitogen-dependent oncogene, has an important role in the progression of human malignancies, whereas tumor suppressor phosphatase and tensin homolog (PTEN) is known to control a variety of processes associated with cell survival, proliferation and invasion. DJ-1 overexpression was

Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells.

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Although tumor resistance remains a significant impediment to successful radiotherapy, associated regulatory markers and detailed molecular mechanisms underlying this phenomenon are not well defined. In this study, we identified inositol polyphosphate 4-phosphatase type II (INPP4B) as a novel marker

[Prognostic value of CDC25 phosphatases expression in laryngeal cancer].

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CDC25 phosphatases, significant positive regulators of the cell cycle play a pivotal role in controlling cell proliferation during development and tumorigenesis. The prevalence and clinical implications of CDC25 immunoreactivity in laryngeal squamous cell cancer (LSCC) patients however, have not

[Biochemical studies of alkaline phosphatase in laryngeal cancer tissue].

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Tumor infiltrating lymphocytes in HLA+ and HLA- laryngeal cancer--quantitative approach.

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In search of factors governing the accumulation of tumor infiltrating lymphocytes (TIL), frozen sections from fresh surgical specimens of laryngeal carcinoma (n = 36) were tested by alkaline phosphatase-anti-alkaline phosphatase (APAAP) immunohistochemistry for monomorphic determinants of HLA class

[Functional status of the lymphocytes and adrenal cortex in preoperative radiotherapy of patients with laryngeal cancer exposed to different oxygen conditions].

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The authors presented the results of study of lymphocytic and adrenal cortical function in preoperative radiotherapy of 38 laryngeal cancer patients in different oxygen regimens: in the air and under the conditions of hyperbaric oxygenation (HBO). A method of mean dose fractionation (a single focal

[Suppression subtractive hybridization to identify differentially expressed gene between laryngeal tumor and the normal tissue adjacant to the tumor].

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OBJECTIVE To screen the differently expressed genes between laryngeal tumor and the normal tissue adjacant to the tumor and construct the subtractive cDNA library. METHODS The subtractive cDNA library was contructed with the suppression subtractive hybridization (SSH) technique. Nine random clones

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.

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Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation.

SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer.

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The overall survival rate and prognosis of patients with laryngeal cancer are not optimistic despite advances in therapeutic techniques. Gene expression prognostic models enable the development of more appropriate treatment strategies. The human gene PTPN11 encoding a non-receptor protein tyrosine

[Lysosomes in invasive laryngeal cancer].

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The occurrence, distribution, morphology and enzymatic activity of lysosomes in malignant keratinocytes of laryngeal carcinoma was studied by electron microscopy and ultrastructural cytochemistry. Lysosomes can be observed in various forms: dense bodies, multivesicular bodies, myelin bodies and

Expression patterns of cyclin E, cyclin A and CDC25 phosphatases in laryngeal carcinogenesis.

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The aim of the research was to evaluate the expression levels of cyclin E/A and CDC25A/B during laryngeal carcinogenesis. The expression was demonstrated using immunohistochemistry in 46 cases of laryngeal cancer (LSCC), 23 epithelial dysplasias (ED) and 21 samples of normal mucosa (NM). The mean

PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy.

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The aim of this study was to establish the prognostic value of the epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on local control in patients with early stage supraglottic laryngeal squamous cell carcinoma (LSCC)

Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck.

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Fas-associated phosphatase-1 is encoded by the protein tyrosine phosphatase, non-receptor type 13 (PTPN13) gene and attributes to the resistance to Fas-mediated apoptosis in several tumors, including squamous cell carcinoma of the head and neck (SCCHN). However, no epidemiological studies have

CIP2A, an oncoprotein, is associated with cell proliferation, invasion and migration in laryngeal carcinoma cells.

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Laryngeal carcinoma is one of the most common malignant tumors in otorhinolaryngology. Moreover, experimental investigation showed that cancerous inhibitor of protein phosphatase 2A (CIP2A) expressed highly in various cancers. Therefore, we investigated whether CIP2A can regulate the proliferation,

Expression of PTEN protein in patients with laryngeal squamous cell carcinoma.

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OBJECTIVE PTEN (phosphatase and tensin homologue deleted on chromosome 10), also referred to as MMAC1 (mutated in multiple advanced cancers) gene was recently identified as a putative tumor suppressor in a variety of malignant tumors. PTEN expression has been investigated in some squamous cell

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Herbal & Natural Medicine

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