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Posterior capsule opacification is a common postoperative complication after extracapsular cataract extraction and lens implantation. If the patient's visual acuity is reduced markedly, a capsulotomy with a Nd-YAG laser may become necessary. Various attempts have been made with the aim of developing
OBJECTIVE
To determine whether apoptosis or necrosis of lens epithelial cells occurs after lens extraction.
METHODS
Lens extraction was performed on 24 rabbit eyes. The authors then performed terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and transmission electron
It has been a clinical impression that posterior chamber lens implants in some way inhibit opacification of the posterior lens capsule after extracapsular cataract extraction. The mechanism of this inhibition is unclear; it may be related to mechanical contact or blockage of migration of lens
Lens repair and calcification have been studied in an experimental rabbit model of anterior segment necrosis. Findings were compared with those in a human senile cataractous lens with subcapsular calcification. Rabbit lenses subjected to anterior segment ischemia underwent a repair process similar
OBJECTIVE
To examine extracellular matrix (ECM) production of lens epithelial cells (LECs) and their regulation by cytokines.
METHODS
Research Laboratory, International Intraocular Implant Training Center, Tianjin Medical University, People's Republic of China.
METHODS
Bovine LECs were cultured with
The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling
The lens has been considered to be an immune privileged site not susceptible to the immune processes normally associated with tissue injury and wound repair. However, as greater insight into the immune surveillance process is gained, we have reevaluated the concept of immune privilege. Our studies
OBJECTIVE
To investigate the relationship among inflammatory reaction and cytokine levels, nitric oxide (NO) content in aqueous humor after intraocular lens implantation.
METHODS
Eighteen New Zealand rabbits were divided randomly into 3 groups (each 6 rabbits): (1) control group, (2) extracapsular
Experimental lens-induced uveitis was produced in Lewis rats by sensitization with bovine lens protein prior to disruption of the lens capsule. Treatment of these animals by intraperitoneal injection of dimethyl sulfoxide resulted in reduction in retinal vasculitis, hemorrhage and necrosis.
The lens of the eye is derived from the non-neural ectoderm situated next to the optic vesicle. Fibroblast growth factor (FGF) signals play a major role at various stages of vertebrate lens development ranging from induction and proliferation to differentiation. Less is however known about the
A large area of conjunctiva and a smaller area of full thickness sclera eroded immediately adjacent to the edge of a soft contact lens. The soft lens was worn to protect the epithelium of a corneal graft in an alkali-burned eye. The conjunctiva-sclera necrosis appears to be a complication of a
OBJECTIVE
To evaluate the importance of lens epithelial cell death in age-related cataract. To determine whether the large percentage of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)-positive lens epithelial cells previously reported in human capsulotomy
We observed the Shearing-style intraocular lens in human cadaver eyes and in dog eyes. In human cadaver eyes the lens loops rest in the ciliary body sulcus without exerting undue pressure; the only major problem occurred when the posterior capsule was torn and a loop found its way into the pars
The aim of this study was to analyze whether symptoms of discomfort in hydrogel contact lens (HCL) wearers were associated with changes in corneal sensitivity or levels of tear inflammatory mediators.
Sixty-six subjects were included: 47 HCL wearers, further divided into 24 symptomatic and 23