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malaria/carbohydrate
Линкът е запазен в клипборда
Страница 1 от 183 резултата
Vaccine-Induced Carbohydrate-Specific Memory B Cells Reactivate During Rodent Malaria Infection.
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A long-standing challenge in malaria is the limited understanding of B cell immunity, previously hampered by lack of tools to phenotype rare antigen-specific cells. Our aim was to develop a method for identifying carbohydrate-specific B cells within lymphocyte populations and to determine whether a
Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets.
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Transmission blocking vaccines (TBV) against mosquito midgut carbohydrate epitopes is a promising approach to curbing the spread of malaria. However, carbohydrates as immunogens can be problematic. Via the malaria transmission blocking monoclonal antibody, MG96, we isolated dodecapeptide mimics of
Carbohydrate binding molecules in malaria pathology.
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Interactions between parasite-encoded proteins and host carbohydrate molecules are essential at multiple stages in the life cycle of the malaria-causing parasite, Plasmodium falciparum, and these interactions are targets for the development of therapeutics to treat the disease. Here we review recent
Studies on glycoproteins in the human malaria parasite Plasmodium falciparum--lectin binding properties and the possible carbohydrate-protein linkage.
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Several glycoproteins of the human malarial parasite Plasmodium falciparum are shown to bind to the lectins concanavalin A, wheat germ agglutinin, Ricinus communis 120 lectin and Bandeirea simplicifolia lectin. There was reduced binding of [125I]-concanavalin A to several red blood cell
A role for carbohydrate moieties in the immune response to malaria.
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Treatment of antigen prepared from asexual blood stages of the human malarial parasite Plasmodium falciparum with a mixture of glycosidases resulted in a reduction in the ability of the antigen to bind antibodies from immune human and monkey sera in an ELISA assay. Some of the epitopes in the
Malaria sporozoites and circumsporozoite protein bind sulfated glycans: carbohydrate binding properties predicted from sequence homologies with other lectins.
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Circumsporozoite (CS) proteins, the major surface proteins of the sporozoites of the various malaria (Plasmodium) species, share a region of highly conserved sequence homology in common with sporozoite surface protein 2 (SSP2) and a group of proteins observed to specifically bind sulfated
Lectin-carbohydrate recognition mechanism of Plasmodium berghei in the midgut of malaria vector Anopheles stephensi using quantum dot as a new approach.
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Potential targets of Plasmodium ookinetes at the mosquito midgut walls were investigated in relation to interfering malarial transmission. In this study, the essential application of Quantum Dots (QDs) was used to examine the interaction between Plasmodium berghei ookinetes and the Anopheles
Effect of antimalarials on the carbohydrate metabolism of malaria parasites.
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1. Metabolic studies on a chloroquine-resistant P. berghei derived from a sensitive strain. 2. Further studies on the carbohydrate metabolism of malaria parasites.
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[Disturbance of carbohydrate metabolism in malaria].
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Role for carbohydrate moieties in immune response to malaria.
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The structure of a chondroitin sulfate-binding domain important in placental malaria.
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Adhesive PfEMP1 proteins are displayed on the surface of malaria-infected red blood cells. They play a critical role in the disease, tethering infected cells away from destruction by the spleen and causing many severe symptoms. A molecular understanding of how these domains maintain their binding
Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses.
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Dendritic cells (DCs) play a crucial role in the development of protective immunity to malaria. However, it remains unclear how malaria parasites trigger immune responses in DCs. In this study, we purified merozoites, food vacuoles, and parasite membrane fragments released during the Plasmodium
Decoding the Role of Glycans in Malaria.
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Complications arising from malaria are a concern for public health authorities worldwide, since the annual caseload in humans usually exceeds millions. Of more than 160 species of Plasmodium, only 4 infect humans, with the most severe cases ascribed to Plasmodium falciparum and the most prevalent to
Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential.
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Най-пълната база данни за лечебни билки, подкрепена от науката
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