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IgG and albumin were determined in cerebrospinal fluid (CSF) and plasma by electroimmuno assay in 90 control patients. The curve for the ratios between concentration of IgG in CSF and in plasma versus the ratios between concentration of albumin in CSF and in plasma was practically linear (r=0.95).
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Liquor:serum quotients of IgG and albumin in patients with meningism, meningitis and multiple sclerosis have been studied. Abnormal quotients indicative of disturbed blood-brain barrier function and/or intrathecal IgG synthesis were found in various proportions of all 3 groups of patients. In some
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To evaluate the diagnostic role of cerebrospinal fluid (CSF) ferritin and albumin index (AI = CSF albumin/serum albumin × 1000) in differentiating acute bacterial meningitis (ABM) from acute viral meningitis (AVM) in children.
The study included 42 cases each of ABM and AVM in pediatric age group.
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The blood-brain barrier (BBB) is a critical extrameningeal site of injury during bacterial meningitis, manifested by enhanced BBB permeability (BBBP). Previous methods to measure altered BBBP during meningitis involve radioactive materials, or are poorly quantified. Europium (EU) is a fluorescent,
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Injury to the blood brain barrier (BBB) is a fundamental sequela of bacterial meningitis, yet the precise mechanism facilitating exudation of albumin across the endothelium of the cerebral microvasculature remains conjectural. After intracisternal inoculation of Escherichia coli (0111:B4)
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OBJECTIVE
To compare the intracranial pressure after resuscitation to normovolemia by using 20% albumin or normal saline in a cat model of meningitis.
METHODS
Prospective, randomized animal study.
METHODS
University hospital laboratory.
METHODS
Twenty adult, male cats.
METHODS
Meningitis was induced
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Urinary albumin excretion (AE) was determined by a sensitive method (below dipstick positive values, 15 to 300 micrograms/minute) in 68 children with meningitis during 48 hours after hospital admission; 51 children had bacterial meningitis (BM) and 17 had aseptic meningitis. AE (results as mean +/-
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BACKGROUND
Inflammatory diseases of the CNS are associated with increased permeability of blood-brain barrier due to vasculitis of cerebral blood vessels leading to regional ischaemia and necrosis. Many substances pass easily from the serum into the CSF through inflamed and damaged blood-brain
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