methanethiol/възпаление

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Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease.

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BACKGROUND The aetiology of inflammatory bowel disease (IBD) remains poorly understood. Recent evidence suggests an important role of gut microbial dysbiosis in IBD, and this may be associated with changes in faecal volatile organic metabolites (VOMs). OBJECTIVE To describe the changes in the faecal

In Vitro Effect of Porphyromonas gingivalis Methionine Gamma Lyase on Biofilm Composition and Oral Inflammatory Response.

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Methanethiol (methyl mercaptan) is an important contributor to oral malodour and periodontal tissue destruction. Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum are key oral microbial species that produce methanethiol via methionine gamma lyase (mgl) activity. The aim of

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.

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Physiological roles of the transsulfuration pathway have been recognized by its contribution to the synthesis of cytoprotective cysteine metabolites, such as glutathione, taurine/hypotaurine, and hydrogen sulfide (H(2)S), whereas its roles in protecting against methionine toxicity remained to be

Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited.

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The concept of synergistic mechanisms as the pathophysiologic basis of hepatic encephalopathy started with the pioneering work of Les Zieve in Minneapolis some 60 years ago where synergistic actions of the liver-derived toxins ammonia, methanethiol, and octanoic acid were described. More recently,

Tinea pedis pathophysiology and treatment.

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Fungal infections of the foot can be divided into three major varieties, all of which have differing pathophysiologic aspects with therapeutic implications. Interdigital infections involve an ecological interplay between dermatophytes and bacteria. Simple scaling types of infection are caused by

Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes.

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Selenium-binding protein 1 (SELENBP1) has recently been reported to catalyse the oxidation of methanethiol, an organosulfur compound produced by gut microbiota. Two of the reaction products of methanethiol oxidation, hydrogen peroxide and hydrogen sulphide, serve as signalling molecules for cell

Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology.

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Chronic inflammation is an established risk factor for colorectal cancer (CRC). To study reactive products of gut inflammation and redox signaling on CRC development we used untargeted adductomics to detect adduct features in pre-diagnostic serum from the EPIC-Italy cohort. We focused on

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Herbal & Natural Medicine

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