nepodin/лапад

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Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.

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Nepodin and chrysophanol, isolated from Rumex nepalensis roots, showed significant cyclooxygenase (COX) inhibitory activity. To further optimize these lead molecules and study structure activity relationship (SAR), eighteen derivatives of nepodin and nine derivatives of chrysophanol were synthesized

Evaluation of raw nepodin extraction from Rumex japonicus and R. obtusifolius and their DNA polymorphisms.

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Nepodin, found in the roots of Rumex japonicus Houtt. (Polygonaceae), inhibits osteoclast differentiation and has an antidiabetic effect. We propose nepodin as an ingredient of new functional foods or as a drug candidate for reducing the risk of reduced locomotion resulting from diseases such as

Inhibition of Biofilm Formation by Candida albicans and Polymicrobial Microorganisms by Nepodin via Hyphal-Growth Suppression.

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Candida albicans is an opportunistic pathogenic yeast and is responsible for candidiasis. It readily colonizes host tissues and implant devices, and forms biofilms, which play an important role in pathogenesis and drug resistance. In this study, the antibiofilm, antihyphal, and antivirulence

Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo.

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Many active components derived from edible natural resources such as plant extracts have recently attracted attention for their potential use as functional foods or drugs for preventing and treating metabolic diseases such as diabetes. To obtain a novel modulator of glucose metabolism, we conducted

Antimalarial activity of nepodin isolated from Rumex crispus.

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The purpose of this study is to define the antimalarial activity of Rumex crispus. To identify an active compound that is isolated from R. crispus, bioassay-based chromatographic fractionation and purification is carried out from 70 % ethanol extract of R. crispus; then, an active compound, nepodin,

[Study on the chemical constituents of Rumex patientia].

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OBJECTIVE To study the chemical constituents of roots of Rumex patientia. METHODS The compounds were separated and purified by silica column chromatopraphy, Sephadex LH-20 and identified by several spectroscopic methods. RESULTS Seven constituents were identified as nepodin (1),

Five naphthalene glycosides from the roots of Rumex patientia.

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Three novel and two known naphthalene glycosides were isolated from the roots of Rumex patientia L. (Polygonaceae). The structures of the new compounds were established, respectively as 2-acetyl-3-methyl-6-carboxy-1,8-dihydroxynaphthalene-8-O-beta-D-glucopyranoside,

[Chemical constituents from aerial part of Rumex patientia].

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OBJECTIVE To study the chemical constituents from aerial part of Rumex patientia. METHODS The compounds were isolated and purified by silica gels and polyamide column chromatography. Their structures were elucidated by physicochemical and spectroscopic evidences. RESULTS Twelve compounds were

Simultaneous determination of naphthalene and anthraquinone derivatives in Rumex nepalensis Spreng. roots by HPLC: comparison of different extraction methods and validation.

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BACKGROUND Rumex nepalensis contains mainly anthraquinone and naphthalene derivatives. Although HPLC methods have been reported for the analysis of anthraquinones, neither a phytochemical analysis of Rumex species nor the simultaneous determination of anthraquinone and naphthalene derivatives in

The production of acetate derived hydroxyanthraquinones, -dianthrones, -naphthalenes and -benzenes in tissue cultures from Rumex alpinus.

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Tissue cultures set up from roots of Rumex alpinus L. were grown on Murashige and Skoog's medium with kinetin and either 2,4-D or NAA as growth factors. The 2,4-D cultures produced a broader spectrum of hydroxyanthracene, hydroxynaphthalene and hydroxybenzene derivatives than the NAA cultures. In

Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free radical scavenging effects of Rumex nepalensis.

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Evaluation of the topical anti-inflammatory activity of chloroform and ethyl acetate extracts of RUMEX NEPALENSIS roots in a TPA-induced acute inflammation mouse model demonstrated a significant reduction in ear edema. The extracts were further tested on purified enzymes for COX-1 and COX-2

Rumex japonicus Houtt.: A phytochemical, pharmacological, and pharmacokinetic review.

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Rumex japonicus Houtt. (RJH-Yang Ti) RJH has been used as a folk medicine in East Asian countries for thousands of years. It has a wide range of therapeutic effects in terms of anti-microorganic, anti-oxidant, anti-inflammatory, and antitumor effects. Therefore, it is urgent to thoroughly review the

[Study on the optimal harvesting time of Rumex gmelini by analyzing the contents of principal components].

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OBJECTIVE To establish a method used for optimization of harvesting time and determine the best time for harvesting Rumex gmelini. METHODS An HPLC method was applied to determinate the contents of seven active constituents(resveratrol, polydatin, chrysophanol 1-glucoside, nepodin, emodin,

[Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].

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OBJECTIVE To provide scientific basis for the selection of agrotype and property fertilization for Rumex gmelini cultivated in compliance with good agricultural practice (GAP). METHODS HPLC method was applied to determinate the content of seven active constituents (resveratrol, polydatin,

The Genus Rumex: Review of traditional uses, phytochemistry and pharmacology.

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BACKGROUND The approximately 200 species of the genus Rumex (sorrel, Polygonaceae) are distributed worldwide (European, Asian, African and American countries). Some species have been used traditionally as vegetables and for their medicinal properties. Based on the traditional knowledge, different

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