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The inhibitory effect of trilinolein on norepinephrine-induced beta-myosin heavy chain promoter activity, reactive oxygen species generation, and extracellular signal-regulated kinase phosphorylation in neonatal rat cardiomyocytes.

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The myocardial protective effects of trilinolein, isolated from the traditional Chinese herb Sanchi (Panax notoginseng), are thought to be related to its antioxidant activity. However, the intracellular mechanism underlying the protective effect of trilinolein in the heart remains unclear. In the

[Comparative effects of Panax notoginseng saponins, verapamil, and norepinephrine on cerebral circulation in anesthetized rats and rabbits].

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In urethane-anesthetized New Zealand rabbits, mean blood pressure (MBP) and cerebrovascular resistance (CVR) fell by 27-47% and 11-17% (P < 0.05), respectively after Panax notoginseng saponins (PNS) 20-80 mg.kg-1 i.v. Verapamil (Ver) 30 micrograms.kg-1 i.v. showed similar effects, but norepinephrine

[Relationship between the inhibitory effects of PNS on cardiac hypertrophy and its action on neurohormonal factor].

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OBJECTIVE To study the effects of total saponins of Panax notoginseng (PNS) on the overall model and vitro model of cardiac hypertrophy, and investigate the mechanism of its action. METHODS Cardiac hypertrophy of rats due to pressure overload was induced by constricting of abdominal aorta. The rats

Ginsenoside Rb3 exerts antidepressant-like effects in several animal models.

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Total ginsenosides have been shown to have therapeutic actions as antidepressants. We report a major active ingredient of total ginsenosides, the ginsenoside Rb3 (Rb3), which may have antidepressant-like effects. Using the forced swim test, tail suspension test, and learned helplessness procedure,

[Effects of panaxadiol saponins isolated from Panax notoginseng on intracellular and extracellular calcium].

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Panaxadiol saponins (PDS) contain saponins Panax notoginseng B1 and E. The spontaneous beating induced by isoproterenol in isolated rat right atria and the increase of contractile force induced by Ca2+ in isolated guinea pig colon were inhibited by PDS 75 and 150 micrograms.ml-1, respectively and

Endothelium-dependent vasodilation effects of Panax notoginseng and its main components are mediated by nitric oxide and cyclooxygenase pathways.

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Panax notoginseng, a traditional Chinese herbal medicine, has been used for the treatment of cardiovascular diseases. The main bioactive components of this species are Panax notoginseng saponins (PNS). The present study aimed to investigate the effects of PNS and five of its main components

Panax ginseng may improve some symptoms of attention-deficit hyperactivity disorder.

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OBJECTIVE In this open trial, Panax ginseng, a serotonin and norepinephrine reuptake inhibitor, actually used as an antidepressant, has been investigated for its efficacy in the treatment of attention-deficit hyperactivity disorder (ADHD) patients. METHODS Three 14-17-year-old male psychiatric

[Effects of saponins from stems and leaves of Panax quinquefolium L. on the contraction of rabbit aortic strips].

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It has been found out that the saponins from stems and leaves of Panax quinquefolium (PQS) can non-competitively antagonize the dose-response curves of norepinephrine (NE), potassium chloride and calcium chloride on the isolated aortic strips of rabbits, and obviously inhibit intracellular and

[Effects of extracts of Ginseng and Ginkgo biloba on hippocampal acetylcholine and monoamines in PDAP-pV717I transgenic mice].

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OBJECTIVE To study the effects and its possible mechanism of Naoweikang (NWK), a composite of ginseng and ginkgo extracts, on hippocampal neurotransmitters in APP transgenic mice. METHODS P-DAPPV717I transgenic mice were taken as the model of Alzheimer's disease (AD) and be treated with different

Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence for an antioxidant intervention.

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The aim of this work was to investigate in the rat the protective effect of an oral administration (one week) of Panax ginseng (PG) extract (10 mg/ml in drinking water; 1.6 g/kg/day) on myocardial post-ischemic damage induced by hyperbaric oxygen (HBO) and on the loss in functionality of the

The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice.

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The effect of ginseng saponins on plasma interleukin-6 (IL-6) in non-stressed and immobilization-stressed mice were investigated. Ginseng total saponins, ginsenosides Rb2, Rg1 and Rd administered intraperitoneally attenuated the immobilization stress-induced increase in plasma IL-6 level. But,

Distinctive effect of ginseng saponins on development of morphine tolerance in guinea-pig ileum and mouse vas deferens.

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Studies on the effect of ginseng saponins on the development of tolerance to morphine have been carried out using isolated preparations of guinea-pig ileum (GPI) and mouse vas deferens (MVD). Incubation of GPI preparation with morphine resulted in the development of tolerance to the inhibitory

The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats.

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The study determined the maximum intraperitoneal (ip) scopolamine dose inducing memory impairment in rats (2 mg/kg) compared to 0.5 or 1 mg/kg dose. The effect reflected by significant increase from normal in the latency time required for rats to find the hidden platform in water maze task and

Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia.

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Recent studies have shown that Panax ginseng has a variety of beneficial effects on the cardiovascular systems. Homocysteine (Hcy), which is derived from L-methionine (Met), has been closely associated with the increased risk of cardiovascular diseases. In the present study, we examined whether in

American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task.

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OBJECTIVE To determine if HT-1001, an extract of American ginseng, affects scopolamine-induced memory and performance deficits in a spatial learning task, alters brain concentrations of aminergic neurotransmitters, and alters choline uptake in synaptosome preparations. METHODS Animal

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