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In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root.

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Scutellariae Radix is one of the well-known tocolytic Chinese herbs. Oroxylin A is isolated from the root of Scutellaria baicalensis. The main syndrome of preterm birth is caused by uterus contractions from excitatory factors. Administration of tocolytic agents is a strategy to prevent the

Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography.

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The medicinal plant Scutellaria baicalensis Georgi has been used widely in traditional Chinese medicine for anti-inflammation, anticancer, antiviral and antibacterial infections, reducing the total cholesterol level and decreasing blood pressures. A high-speed counter-current chromatography (HSCCC)

Exploring the effective materials of flavonoids-enriched extract from Scutellaria baicalensis roots based on the metabolic activation in influenza A virus induced acute lung injury.

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Flavonoids-enriched extract from Scutellaria baicalensis roots (FESR) ameliorated influenza A virus (IAV) induced acute lung injury (ALI) in mice by inhibiting the excessive activation of complement system in vivo. However, FESR had no anti-complementary activity in vitro. In order to reveal the

Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root.

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A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABAA receptors with a

[Analysis of main flavonoids contents of Scutellaria baicalensis].

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OBJECTIVE To develop a HPLC-DAD method for simultaneous determination of six flavonoids in Scutellaria baicalensis, and study the effect of geographic sources, culturation, harvesting time and processing on the contents of flavonoids. METHODS The analysis was performed on a Thermo ODS-2 Hypersil

Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells.

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The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance by apoptosis of hepatic stellate cells (HSCs), which play a central role in liver fibrogenesis. In this study, the apoptotic effect of wogonin, oroxylin A, 2',5,6',7-tetrahydroxyflavone, skullcapflavone I,

Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis.

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As an important herbaceous plant, Scutellaria baicalensis Georgi (Chinese skullcap) is geographically widespread and commonly used throughout the world. In the Chinese medicine market, S. baicalensis has been divided into two primary types, "Ku Qin" (WXR) and "Tiao Qin" (TST). Moreover, TST is also

Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components.

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Scutellaria baicalensis Georgi is a traditional Chinese medicinal plant. The effects of arsenic (As) on the growth and the formation of pharmaceutical components of S. baicalensis, and the uptake and accumulation of As by S. baicalensis were investigated using a field pot-culture experiment. The

[Influence of cutting seedling on growth, quality and yield of both aerial and underground part by cutting seedling in Scutellaria baicalensis].

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By measuring the growth data of Scutellaria baicalensis in different cutting-seedling and determined active ingredient contents by HPLC and ultraviolet spectrophotometric determination. such as flavonoids. baicalin. wogonoside. baicalein. wogonin. oroxylin A. scutellarin. luteolin. and apigenin in

[Comparative and correlational studies on contents of flavonoids in axial root and lateral root of Scutellaria baicalensis].

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OBJECTIVE To compare the contents of flavonoids in axial root and lateral root of Scutellaria baicalensis, and study their correlation. METHODS The contents of 5 major flavonoids, baicalin, wogonoside, baicalein, wogonin and oroxylin A, were determined in axial root and lateral root of S.

[HPLC fingerprint of flavonoids of Kushen Tang and its correlation to Scutellaria baicalensis and Sophora flavescens].

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OBJECTIVE To establish the HPLC fingerprint of the flavonoids of Kushen Tang, and to study its correlation to Scutellaria baicalensis and Sophora flavescens. METHODS The fingerprints of the flavonoids of Kushen Tang were established by HPLC under two detective wavelengths 280 nm and 365 nm. The

Flavonoids from Scutellaria baicalensis inhibit senescence-associated secretory phenotype production by interrupting IκBζ/C/EBPβ pathway: Inhibition of age-related inflammation

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Background: Prolonged exposure to the senescence-associated secretory phenotype (SASP) with age leads to chronic low-grade inflammation in neighboring cells and tissues, causing many chronic degenerative diseases.

Antithrombotic activities of oroxylin A in vitro and in vivo.

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Here, the anticoagulant activities of oroxylin A (OroA), a major component of Scutellaria baicalensis Georgi, were examined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT), and the activities of cell-based thrombin and activated factor X (FXa). Furthermore, the

The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice.

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Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive

Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells.

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Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12

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