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Smokeless tobacco and osteoporosis: a new relationship?

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Osteoporosis is a common disorder of bone predominantly affecting postmenopausal women in which bone mineral density declines making bone more likely to break. Although cigarette smoking is a well-established risk factor for osteoporosis, smokeless tobacco (ST) use has never been suggested or

The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis.

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Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts

Low level nicotine: a novel approach to reduce osteoporosis incidence.

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Osteoporosis is a serious health problem worldwide and leads to a significant burden on society. Unfortunately, efforts to control osteoporosis are largely unsuccessful. Lowering an individual's risk for osteoporosis must focus not only on treatment but also on modification of risk factors. One of

Smoking-induced risk of osteoporosis is partly mediated by cadmium from tobacco smoke: The MrOS Sweden Study.

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Cigarette smoking is a risk factor for osteoporosis and bone fracture. Moreover, smoking causes exposure to cadmium, which is a known risk factor for osteoporosis. It is hypothesized that part of smoking-induced osteoporosis may be mediated via cadmium from tobacco smoke. We investigated this

Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis.

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Nicotine contained in cigarette smoke contributes to the onset of several diseases, including osteoporosis, whose emerging pathogenic mechanism is associated with osteoblasts apoptosis. Scanty information is available on the molecular mechanisms of nicotine on osteoblasts apoptosis and,

[Tobacco as risk factor of osteoporosis, myth or reality?].

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To evaluate smoking as a risk factor for osteoporosis, we performed a qualitative analysis of 40 international studies investigating statistical associations between smoking and osteoporosis related endpoints. Using standardized causality assessment criteria, we failed to demonstrate a relationship

Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men.

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In a group of 11 men ranging in age from 35 to 50 years with idiopathic osteoporosis, most were mild alcoholics and heavy smokers. Two had absorptive hypercalciuria. Histomorphometry showed that the patients had low trabecular bone volume and mean trabecular thickness when compared with age-matched

Possible influence of nicotine on osteoporosis.

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The effect of chronic nicotine administration on bone mineral content in mice.

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Tobacco use has been identified as being a risk factor for the development of osteoporosis. To elucidate the effect of nicotine on bone metabolism we examined 8 intact and 8 castrated mice treated for 56 days with nicotine in drinking water and compared with the same number of mice acting as

Bone biomechanical property deterioration due to tobacco smoke exposure.

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Tobacco smoking has been implicated in the development of osteoporosis and early onset of menopause in women smokers. We measured various biomechanical properties of femurs and tibiae obtained from smoke-exposed and control mice to determine cigarette smoke influences on bone mass, structure, and

Nonpharmacological interventions for osteoporosis treatment: Systematic review of clinical practice guidelines.

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The aim of this study was to perform a systematic review of clinical practice guidelines to identify nonpharmacologic recommendations for osteoporosis treatment.A systematic review of literature following PRISMA (Preferred Reporting Items for Systematic

Osteoporosis: preventive strategies.

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In the United States alone, osteoporosis affects over 20 million women. The cost of treating the complications of osteoporosis exceeds 10 billion dollars. Half of those who sustain a hip fracture never return to their former life style. In addition, there is a major increase in mortality within the

Why should patients with systemic disease and tobacco smokers go to the dentist?

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Periodontal diseases (PD) affect about half of the adult population all over the world. PD is caused by bacterial infection which induces an inflammatory response with progressive destruction of the periodontal tissues and finally the loss of teeth. Tobacco smoking (TS), alcohol consumption, and

Salivary variables in relation to tobacco smoking and female sex steroid hormone-use in 30 to 59-year-old women.

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Several systemic conditions may have an influence on oral health. Hormone replacement therapy (HRT) has a positive effect on alveolar bone of menopausal women and smoking a negative effect. However, little is known about their effect on saliva. The purpose of this study was to examine the effect of

The Impact of Tobacco Cigarette Smoking on Spinal Cord Stimulation Effectiveness in Chronic Spine-Related Pain Patients.

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OBJECTIVE Despite the observation that select nicotine receptor agonists have analgesic effects, smokers report higher pain scores and more functional impairments than lifelong nonsmokers, attributable to exaggerated stress responses, receptor desensitization, and altered pharmacokinetics compounded

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