oxygenase/възпаление

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Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation

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TECHNICAL FIELD The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products. BACKGROUND Heme oxygenase-1 (HO-1) catalyzes the first step in the degradation of heme. HO-1 cleaves the .alpha.-meso carbon bridge of b-type heme molecules by oxidation

Fumarate-CO-releasing molecule hybrids, their use in the treatment of inflammatory or cardiovascular diseases and their process of preparation

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FIELD OF THE INVENTION The present invention relates to hybrid fumarate-CO-releasing molecules capable of activating heme oxygenase-1 (HO-1) activity and HO-1 protein expression, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory and

Use of 3-(arylmethyleneamino)-1-aryl-2-pyrazolines in the prophylaxis and treatment of inflammation, pain, pyresis, and asthma

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This invention relates to heterocyclic compounds and their preparation and to the use of such compounds of pharmaceutical formulations thereof in medicine in a mammal, including man, as e.g. anti-inflammatory or anti-allergic agents or as agents in the prevention of tissue rejection. Accordingly,

Procyanidin and cyclo-oxygenase modulator compositions

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FIELD OF THE INVENTION This invention relates o cocoa extracts and compounds therefrom such as polyphenols preferably polyphenols enriched with procyanidins. This invention also relates to methods for preparing such extracts and compounds, as well as to uses for them; for instance, as antineoplastic

Pharmaceutical control of inflammation

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to the control of the inflammatory response, to pharmaceuticals that inhibit or decrease inflammation, to pharmaceuticals that promote, induce or increase inflammation and to treatment of disease states by inhibiting or

Phenylpyrazolidine acetic acid derivatives

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This invention relates to novel phenyl-pyrazolidine acetic acid derivatives possessing lipoxygenase/cyclooxygenase inhibitory activity, which are useful as anti-inflammatory and analgesic agents. It is known that arachidonic acid (AA) is metabolized in mammals by two distinct pathways. The

Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention provides substituted fused imidazole derivatives that may be useful for control of an inflammatory response. In addition, the invention provides compounds, pharmaceutical compositions, and methods of use thereof for

Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

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BACKGROUND OF THE INVENTION Field of the Invention The present invention provides substituted fused imidazole derivatives that may be useful for control of an inflammatory response. In addition, the invention provides compounds, pharmaceutical compositions, and methods of use thereof for controlling

Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease

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TECHNICAL FIELD This invention describes a nutritional composition and method of use for prevention of Parkinson's disease, therefore relating to the fields of nutrition, pharmacology, neurology, pathophysiology, medicine and movement disorders. DESCRIPTION OF THE RELATED ART Parkinson's disease

Antiinflammatory pyrazole thioureas

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This invention relates to formulations comprising heterocylic compounds and their preparation, to their use in medicine in a mammal, including man, e.g. as anti-inflammatory or anti-allergic agents or as agents in the prevention of tissue rejection, and to certain novel heterocylic compounds and

Synthesis and biological activities of new tricyclic-bis-enones (TBEs)

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BACKGROUND OF THE INVENTION I. Field of the Invention The present invention provides novel tricyclic-bis-enone derivatives (TBEs), as well as the process for the preparation of such TBEs, for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis,

Synthesis and biological activities of new tricyclic-bis-enones (TBEs)

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