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The rationale for the development of new drug combinations is to combine optimal doses of drugs with single agent activity which are not cross-resistant and have non-overlapping toxicities. Anthracyclines are widely accepted as the agents of choice for first-line treatment of metastatic breast
BACKGROUND
Breast cancer seldom leads to uterine metastases, but more frequently spreads to the ovaries.
METHODS
A 72 year-old woman treated 28 years earlier for a breast cancer (conservative treatment and ovarian castration through radiotherapy) presented with metrorrhagia. The hysteroscopy and
Adult women require routine care for the acute and chronic health problems found in both sexes, and they require specialized care for women's health problems, including disease prevention, disease screening, and disease management. Internists should direct primary care and participate in specialized
OBJECTIVE
To evaluate the efficacy of mifepristone, a potent antagonist of progesterone and glucorticoids, in the management of cancer and disorders related to reproduction.
METHODS
Reports describing clinical trials of mifepristone treatment of leiomyoma, breast cancer, endometriosis and meningioma
Pudendal nerve entrapment (PNE) is an uncommon cause of chronic pain. Pudendal nerve entrapment typically occurs when the pudendal nerve is fused to nearby anatomical structures or trapped between the sacrotuberous and sacrospinalis ligaments. Pudendal nerve entrapment can be caused by excessive
To assess hormone replacement therapy (HRT) prescription pattern in patients undergoing premature surgical menopause based on surgical indication.Retrospective cohort study SETTING: Academic tertiary care center PATIENTS: Surgically menopausal patients age OBJECTIVE
To identify the strategies (interactive and educational) used by physicians and nurses in gynecology consultations and the length of consultations.
METHODS
We performed an exploratory descriptive study. A questionnaire was used to interview 5 health professionals working in a gynecology
The authors -- about a series of 124 cancerous patients treated during the 12 last years with open spino-thalamic cordotomy for intractable pain -- have tried to evaluate effectiveness of the operation with regard to its levels in relation to the site of pain. Patients suffering median or bilateral
Sickness absenteeism in public institutions compromises the execution of services, and may also generate direct impacts on the population that receives coverage. To determine if sick leave duration for temporary disabilities is associated with non-work-related illnesses (NWRI), a historical cohort
Endometriosis and fibroids are estrogen-dependent benign pathologies of the uterus, which account for infertility and pelvic pain along with dysmenorrhea in women. Suppression of the disease and recurrence after discontinuing hormone therapy strongly suggests that these are responsive to hormones,
OBJECTIVE
The objective of this study was to compare office feasibility, patient acceptance, and diagnostic accuracy of hysteroscopy (HYS) and saline infusion sonography (SIS) in breast cancer patients taking tamoxifen.
METHODS
Sixty-six asymptomatic postmenopausal women on tamoxifen for breast
OBJECTIVE
To analyze clinicopathologic patterns of early ovarian carcinoma.
METHODS
Retrospective chart and histopathology review.
METHODS
Mount Sinai School of Medicine, New York and the Centre Jean Perrin, Clermont Ferrand, France.
METHODS
Seventy-six consecutive cases of Fédération Internationale
BACKGROUND
New high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) methods are among the most successful approaches to improve specificity problems inherent in many immunoassays.
BACKGROUND
We emphasize problems with immunoassays for the measurement of steroids and review the
OBJECTIVE
To review the risks and benefits of elective oophorectomy and to make a clinical recommendation for an appropriate age when benefits of this procedure outweigh the risks.
METHODS
The risks and benefits of oophorectomy as detailed in published articles are reviewed with regard to
BACKGROUND
Patients with ovarian cancer often report having symptoms for months before diagnosis, but such findings are subject to recall bias. The aim of this study was to provide an objective evaluation of symptoms that precede a diagnosis of ovarian cancer.
METHODS
Medicare provider claims linked