phosphatidyl serine/атрофия

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beta-Amyloid-Induced Tau Phosphorylation does not Correlate with Degeneration in Cultured Neurons.

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Treatment of cultured neurons with beta-amyloid (Abeta) evokes multiple consequences, including calcium influx, production of reactive oxygen species (ROS), hyperphosphorylation of tau. Which of these events is the major cause of Abeta-induced neurodegeneration has been the subject of controversy.

Stage-specific degeneration of germ cells in the seminiferous tubules of non-obese diabetic mice.

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The cause of fertility problems in insulin-dependent diabetes is largely unknown. To evaluate the role of autoimmunity-associated phenomena in the testis as a possible cause of the derangement in spermatogenesis, the stage-specific apoptosis of germ cells in the insulitis phase of pre-diabetes was

The British Comparative Thromboplastin: the relationship between lipid class composition and procoagulant activity.

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Twenty-eight consecutive batches of the reference reagent British Comparative Thromboplastin (BCT) were produced in the National (UK) Reference Laboratory for Anticoagulant Reagents and Control (NRLARC) between 1969 and 1977. The relationship between procoagulant activity and lipid class composition

Neuroprotective actions of Selegiline in inhibiting 1-methyl, 4-phenyl, pyridinium ion (MPP+)-induced apoptosis in SK-N-SH neurons.

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We have examined mitochondrial membranes and molecular hallmarks of apoptosis in response to increasing concentrations of 1-Methyl, 4-phenyl, Pyridinium ion (MPP(+)) in SK-N-SH neurons and have evaluated the neuroprotective potential of Selegiline with a primary objective to explore its mechanism(s)

Role of thymic stromal cell dysfunction in the thymic involution of mammary tumor-bearing mice.

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The growth of D1-DMBA-3 mammary tumors leads to a profound thymic atrophy in the hosts. In previous studies we have shown a minor increase in thymic apoptosis in tumor bearers and an early block in the maturation of double negative cells was observed in the thymuses of tumor-bearing mice. We now

Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity.

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Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intreaeritoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed phospholipids, cholesterol

Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity.

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Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intraperitoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed significant decrease in the

Nephrocalcinosis in vitro.

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In order to study the mechanism of dystrophic calcification, an anoxic incubation of rat renal cortex in a tissue culture medium was performed in vitro. Calcium and phosphate in the medium were adjusted to 1.6 and 1.2 mM/1 respectively. Calcification occurred in apposition to the inner surface of

Lipid matrix of dystrophic calcification and urinary stone.

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The concept that phospholipids, phosphatidyl serine (PS) in particular, play a role in tissue calcification has emerged recently and progressed rapidly. Membranous cellular degradation products upon various tissue injuries apparently serve as nidi of calcium apatite nucleation. In view of the strong

Peripheral nerve phospholipid composition: development in normal nerve and age-dependent changes in Wallerian degenerated nerve.

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The phospholipid composition of normal peripheral nerve as a function of developmental age as well as that of Wallerian-degenerated nerve as a function of age at nerve transection and duration of Wallerian degeneration have been quantitated in rabbit sciatic nerve. During development, increases in

[Changes in phospholipids in the gray and white matter of the rat brain during postmortem autolysis dynamics].

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Content of total phospholipids and their individual fractions, studied in rat brain grey and white substances during postmortal autolysis, was distinctly and dissimilarly altered in these tissues and the rate of alterations depended on time of incubation. Relative content of phosphatidyl serines +

Lipids of human retina, retinal pigment epithelium, and Bruch's membrane/choroid: comparison of macular and peripheral regions.

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OBJECTIVE To understand the difference between macular and peripheral regions, tissue samples of human retina, retinal pigment epithelium, and Bruch's membrane/choroid were dissected and analyzed for lipid composition. METHODS To facilitate dissections and enhance the recovery of tissues, eyecups

Valeriana wallichii root extracts and fractions with activity against Leishmania spp.

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Leishmanial diseases, posing a public health problem worldwide, are caused by Leishmania parasites with a dimorphic life cycle alternating between the promastigote and amastigote forms. Promastigotes transmitted by the vector are transformed into amastigotes residing in the host tissue macrophages.

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