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Changes in phospholipids and free fatty acids in the brains of mice preconditioned by hypoxia.

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Changes in the composition and contents of phospholipids and free fatty acids were observed and compared in three groups: (A) unpreconditoned normal controls, (B) exposure to 1 run of hypoxia and (C) exposure to 4 runs of hypoxia. In group B, the content of phosphatidyl ethanolamine (PE),

[Lipid spectrum characteristics of the myocardium of white rats in hypoxic hypoxia].

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By a modified microthin-layer chromatography in the total lipid spectrum of the cardiac muscle of white rats exposed to acute oxygen deficiency in an altitude chamber was investigated. It was found that the content of total lipids, phospholipids, free cholesterol, free fatty acids and triglycerides

Hypoxia-independent apoptosis in neural cells exposed to carbon monoxide in vitro.

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The neurotoxic effects of carbon monoxide (CO) are well known. Brain hypoxia due to the binding of CO to hemoglobin is a recognized cause of CO neurotoxicity, while the direct effect of CO on intracellular targets remains poorly understood. In the present study, we have investigated the pathways

Positron emission tomography imaging of brain tumors.

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Energy metabolism and amino acid transport and incorporation are important components of the pathophysiology of gliomas, about which molecular imaging is providing regional biologic information that is useful to clinical practice. Imaging hypoxia is straightforward and proliferation imaging with FLT

Rheology of the sickle cell disorders.

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The sickling process causes secondary changes in cell shape, size, cation and water content, and membrane structure that contribute to the impairment of intrinsic cell deformability (Figure 2). This rheological defect is partially compensated by a low haematocrit, which moderates the rise in

Determination of membrane lipid differences in insulin resistant diabetes mellitus type 2 in whites and blacks.

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OBJECTIVE Insulin resistance in diabetes mellitus type 2 (DM2) can result from membrane lipid alterations. Blacks are at a higher risk of developing DM2; therefore, we investigated whether membrane lipid differences exist between blacks and whites and if differences contribute to impaired insulin

Molecular imaging of tumor metabolism and apoptosis.

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Increased metabolism has been found to be one of the most prominent features of malignant tumors. This property led to the development of tracers for the assessment of glucose metabolism and amino acid transport and their application for tumor diagnosis and staging. Prominent examples are

Design of the DREPAGREFFE trial: A prospective controlled multicenter study evaluating the benefit of genoidentical hematopoietic stem cell transplantation over chronic transfusion in sickle cell anemia children detected to be at risk of stroke by transcranial Doppler (NCT 01340404).

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Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including

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