quinine/повръщане

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In Vivo Efficacy of Artemether-lumefantrine and Amodiaquine-artesunate in Mozambican Children (MEFI_III)

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Вход / Регистрация

This study followed WHO recommendations for in vivo antimalarial efficacy trials. The study population comprised children aged 6 to 59 months with microscopically confirmed acute uncomplicated malaria. Other inclusion criteria included body weight ≥5kg, the presence of fever (≥37.5°C axillary) or a

TES Artemether-lumefantrine for Pf and Chloroquine (CQ) for Pv

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1. BACKGROUND In 2002, the Philippines changed its antimalarial drug policy to the combination treatment, CQ+ Sulphadoxine-pyrimethamine (SP) as 1st-line treatment and artemether-lumefantrine as 2nd-line treatment. The Department of Health (DOH) prescribed the use of artemether-lumefantrine (AL)

Tolerability and Efficacy of Artemether-Lumefantrine Versus Artesunate + Amodiaquine in Zanzibar

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Вход / Регистрация

Combination therapy, the new strategy for malaria treatment, is based on the hypothesis that two (or more) components of different mechanisms of action protect each other from development of resistance. Artemisinin as well as its two derivatives, e.g. artemether and artesunate, constitute a family

Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa

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Malaria incidence has increased two- to three-folds over the past four decades, and nearly half the world's population now lives in regions endemic for malaria: In Asia, Africa, and South America. A global annual estimate of 300-500 clinical cases of malaria and mortality in the range of 1-2 million

P. Falciparum Resistance to Artemisinin in Vietnam

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3.1 Study Design This study is designed as a randomized open label 42-day follow-up study to evaluate the clinical and parasitological responses after treatment of uncomplicated P.falciparum infections with either AS or DHA-PPQ. Symptomatic patients with P.falciparum mono-infections, fulfilling the

Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam

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3.1 Study Design This study is designed as a 42-day drug efficacy study to evaluate clinical and parasitological responses after treatment of P.vivax malaria infections. Symptomatic patients with P. vivax mono-infections, meeting the study criteria, will be enrolled into the study, and treated with

In Vivo Efficacy of Artemether-lumefantrine and Amodiaquine-artesunate in Mozambican Children

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Вход / Регистрация

Improving Anti-malarial Treatment Options in Guinea-Bissau - Part A

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Background Plasmodium falciparum causes malaria and approximately 665 000 deaths each year. Previously chloroquine (CQ) and sulphadoxine-pyrimethamine were the principle drugs for the treatment of malaria. Due to widespread resistance to these drugs1, the World Health Organization recommends that P.

Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia

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Primary objective: To assess the level of resistance to artemisinin derivatives in Western Cambodia. Secondary objective: To assess the level of resistance to other antimalarial drugs in Western Cambodia 1. Background; There are worrying signs from Western Cambodia that parasitological responses to

Kilimanjaro IPTi Drug Options Trial

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1. Study design The overall study design is a randomised trial of four treatment regimes in two different transmission settings. The four treatment regimes are as follows: (1) placebo, (2) mefloquine; (3) Lapdap; (4) SP. All medications will be given at the time of immunisation with DPT/polio 2,

A Trial of Antimalarial Drugs Used in Pregnancy in Tanzania

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The objectives of this study are to assess the therapeutic efficacy and safety of SP as the current first line drug, and three other potential alternative combinations in treating uncomplicated falciparum malaria during pregnancy, in an area with appreciable levels of SP resistance and rising HIV

Prevention of Severe Anaemia in Gambian Children

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Objectives 1. To assess the effectiveness of monthly prophylaxis with S/P on haematological recovery in children who have been treated for severe anaemia. 2. To measure compliance with the intervention 3. To investigate whether or not infection with chloroquine and S/P resistant strains contributes

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