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quinoline/затлъстяване
Линкът е запазен в клипборда
Страница 1 от 21 резултата
Quinoline derivatives
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BACKGROUND OF THE INVENTION
The present invention is concerned with novel quinoline derivatives useful as neuropeptide Y (NPY) receptor ligands, particularly neuropeptide Y (NPY) antagonists, and even more particularly selective neuropeptides Y Y5 receptor antagonists. Accordingly, the compounds of
Quinoline derivatives
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BACKGROUND OF THE INVENTION
The present invention is concerned with novel quinoline derivatives useful as neuropeptide Y (NPY) receptor ligands, particularly neuropeptide Y (NPY) antagonists, and even more particularly selective neuropeptides Y Y5 receptor antagonists. Accordingly, the compounds of
Quinoline derivatives
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BACKGROUND OF THE INVENTION
The present invention is concerned with novel quinoline derivatives useful as neuropeptide Y (NPY) receptor ligands, particularly neuropeptide Y (NPY) antagonists, and even more particularly selective neuropeptides Y Y5 receptor antagonists. Accordingly, the compounds of
Quinoline derivatives
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BACKGROUND OF THE INVENTION
The present invention is concerned with novel quinoline derivatives useful as neuropeptide Y (NPY) receptor ligands, particularly neuropeptide Y (NPY) antagonists, and even more particularly selective neuropeptides Y Y5 receptor antagonists. Accordingly, the compounds of
Quinoline derivatives
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BACKGROUND OF THE INVENTION
Neuropetide Y is a 36 amino acid peptide that is widely distributed in the central and peripheral nervous systems. This peptide mediates a number of physiological effects through its various receptor subtypes. Studies in animals have shown that neuropeptide Y is a
Tetrahydro-quinoline derivatives
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PRIORITY TO RELATED APPLICATION(S)
This application claims the benefit of PCT/CN2010/074931, filed Jul. 2, 2010, which is hereby incorporated by reference in its entirety.
FIELD OF THE INVENTION
The invention relates to compounds which are activators of AMP-activated protein kinase (AMPK) and which
Substituted naphthyridine and quinoline compounds as MAO inhibitors
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BACKGROUND
Field
The present invention relates to certain disubstituted 1,5-naphthyridine and quinoline compounds as inhibitors of monamine oxidase, and monoamine oxidase B in particular; derivatives of such compounds; compositions of such compounds; methods of making them; and their use in various
Substituted naphthyridine and quinoline compounds as MAO inhibitors
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BACKGROUND
1. Field
The present invention relates to certain disubstituted 1,5-naphthyridine and quinoline compounds as inhibitors of monamine oxidase, and monoamine oxidase B in particular; derivatives of such compounds; compositions of such compounds; methods of making them; and their use in
Substituted naphthyridine and quinoline compounds as MAO inhibitors
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BACKGROUND
Field
The present invention relates to certain disubstituted 1,5-naphthyridine and quinoline compounds as inhibitors of monoamine oxidase, and monoamine oxidase B in particular; derivatives of such compounds; compositions of such compounds; methods of making them; and their use in various
Substituted naphthyridine and quinoline compounds as MAO inhibitors
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Вход / Регистрация
BACKGROUND
1. Field
The present invention relates to certain disubstituted 1,5-naphthyridine and quinoline compounds as inhibitors of monamine oxidase, and monoamine oxidase B in particular; derivatives of such compounds; compositions of such compounds; methods of making them; and their use in
7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
7[4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
Pyrrolo(oxo)quinolines as 5HT ligands
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BACKGROUND
The neurotransmitter/hormone serotonin (5-hydroxytryptamine, 5-HT) regulates many physiological processes via a group of at least 14 distinct receptors that are organized into 7 subfamilies (Hoyer, D., et al., Pharmacol. Rev., 46, 1994). The 5-HT.sub.2 subfamily is composed of the
Quinoline compound
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TECHNICAL FIELD
The present invention relates to a quinoline compound having a melanin-concentrating hormone (hereinafter sometimes to be abbreviated as MCH) antagonistic action and useful as an agent for preventing or treating obesity and the like.
BACKGROUND ART
Feeding behavior is an
Aryl-quinoline derivatives
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FIELD OF THE INVENTION
The present invention relates to organic compounds useful for therapy or prophylaxis in a mammal, and in particular to fatty-acid binding protein (FABP) 4 and/or 5 inhibitors, more particularly dual FABP 4/5 inhibitors for the treatment or prophylaxis of lipodystrophy, type 2
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