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sphingosine/рак
Линкът е запазен в клипборда
Страница 1 от 38 резултата
Sphingosine pathway modulating compounds for the treatment of cancers
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FIELD OF THE INVENTION
The invention relates to the field of pharmaceutical treatment of cancers.
BACKGROUND
Sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule over 20 years ago. Studies have since identified two related kinases, sphingosine kinase 1 and 2 (a/k/a
Sphingosine pathway modulating compounds for the treatment of cancers
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FIELD OF THE INVENTION
The invention relates to the field of pharmaceutical treatment of cancers.
BACKGROUND
Sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule over 20 years ago. Studies have since identified two related kinases, sphingosine kinase 1 and 2 (a/k/a
Sphingosine pathway modulating compounds for the treatment of cancers
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FIELD OF THE INVENTION
The invention relates to the field of pharmaceutical treatment of cancers.
BACKGROUND
Sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule over 20 years ago. Studies have since identified two related kinases, sphingosine kinase 1 and 2 (a/k/a
Sphingosine pathway modulating compounds for the treatment of cancers
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Вход / Регистрация
FIELD OF THE INVENTION
The invention relates to the field of pharmaceutical treatment of cancers.
BACKGROUND
Sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule over 20 years ago. Studies have since identified two related kinases, sphingosine kinase 1 and 2 (a/k/a
Method for detecting sphingosine-1-phosphate (S1P) for cancer detection
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FIELD OF THE INVENTION
The present invention relates to non-radioactive enzymatic methods for detecting Sphingosine-1-Phosphate (S1P) in biological fluids and the correlation at a measurement of S1P to disease. The present invention further relates to a method of detecting the presence of cancer in
Compositions and methods of sphingosine kinase inhibitors in radiation therapy of various cancers
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FIELD OF THE INVENTION
The present invention relates in general to treatment of diseases. More specifically, the invention provides compositions comprising sphingosine kinase inhibitors and methods of using the compositions in radiation therapy for the treatment of various cancers.
BACKGROUND OF THE
Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer
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STATEMENT REGARDING SEQUENCE LISTING
The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the text file containing the Sequence Listing is
Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer
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STATEMENT REGARDING SEQUENCE LISTING
The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the text file containing the Sequence Listing is
Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents
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CROSS REFERENCE TO RELATED APPLICATIONS
This disclosure relates to the S1P receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists described in a patent application entitled "Sphingosine-1-Phosphate
Sphingosine kinase inhibitors
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Reference is made to PCT patent application Serial Number PCT/US2013/025341, published as WO2013/119946, the disclosure of which is incorporated by reference in its entirety.
BACKGROUND
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cellular processes,
Imidamide sphingosine kinase inhibitors
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BACKGROUND
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family. The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation
Imidamide sphingosine kinase inhibitors
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BACKGROUND
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family. The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation
Compositions and methods for inhibiting sphingosine kinase
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BACKGROUND OF THE INVENTION
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family. The EDG receptors are G-protein coupled receptors (GPCRs) and on
Acetanilide sphingosine-1-phosphate receptor antagonists
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FIELD OF THE INVENTION
This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the SIP receptor antagonists. In particularly, this disclosure relates to sphingosine-1-phosphate
Sphingosine kinase type 1 inhibitors and uses thereof
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 7, 2016, is named ENZ-91-CIP-D1-CON-SL.txt and is 657 bytes in size.
FIELD OF THE
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