stearic acid/епилептични припадъци

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The influence of bicuculline-induced seizures on free fatty acid concentrations in cerebral cortex, hippocampus, and cerebellum.

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Using ventilated rats maintained on N2O-O2 (70:30, vol/vol) we induced continuous seizures with i.v. bicuculline and analysed free fatty acids (FFA) in cerebral cortex, hippocampus, and cerebellum after seizures durations of 1-120 min. In the cerebral cortex, peak FFA concentrations were observed

Cerebral phosphoinositide, triacylglycerol and energy metabolism during sustained seizures induced by bicuculline.

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In ventilated rats, levels of phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP), phosphatidylinositol 4,5-bisphosphate (PIP2), diacylglycerol (DAG), triacylglycerol (TAG), free fatty acids (FFA) and phosphatidic acid, as well as their fatty acid contents, were measured in forebrain

Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice.

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The effects of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole were studied in mice. After i.p. injection capric, lauric, myristic, palmitic and stearic acid delayed the onset of picrotoxin-induced clonic convulsion in a dose-dependent manner. The survival time

GC-MS-Based metabolomics discovers a shared serum metabolic characteristic among three types of epileptic seizures.

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Understanding the overall and common metabolic changes of seizures can provide novel clues for their control and prevention. Here, we aim to investigate the global metabolic feature of serum for three types of seizures. We recruited 27 patients who had experienced a seizure within 48h (including 11

Endogenous asymmetry of rat brain lipids and dominance of the right cerebral hemisphere in free fatty acid response to electroconvulsive shock.

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An asymmetric distribution of free fatty acids (FFA) is shown to occur between right and left cerebral hemispheres (RCH, LCH) of the rat. The RCH contains 35% less FFA than the LCH, the difference being mainly accounted for by saturated and monoenoic fatty acids. Acute and chronic electroconvulsive

Stimulation of free fatty acid and diacylglycerol accumulation in cerebrum and cerebellum during bicuculline-induced status epilepticus. Effect of pretreatment with alpha-methyl-p-tyrosine and p-chlorophenylalamine.

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The pool size and composition of free fatty acids (FFA) and diglycerides (DG) from the cerebrum and cerebellum of rats undergoing bicuculline-induced seizures were studied. A fourfold increase in cerebral FFA occurred 3-4 min after bicuculline injection; arachidonic and stearic acids were the

Does valproate therapy in epileptic patients contribute to changing atherosclerosis risk factors? The role of lipids and free fatty acids.

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BACKGROUND We aimed to demonstrate the relationship between the valproate (VPA) treatment versus lipid and serum free fatty acids (FFAs) profiles to be the potential atherosclerosis risk factor in epileptic patients. METHODS Fasting blood samples were taken from 21 adult VPA-treated patients and 21

Superparamagnetic Iron Oxide-Loaded Lipid Nanocarriers Incorporated in Thermosensitive In Situ Gel for Magnetic Brain Targeting of Clonazepam.

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The objective of the study was to target clonazepam to the brain through the intranasal olfactory mucosa using nanolipid carriers loaded with superparamagnetic iron oxide nanoparticles (SPIONs) to allow nanocarrier guidance and retention with an external magnetic field. For improved delivery, the

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