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triptolide/възпаление
Линкът е запазен в клипборда
12 резултата
Triptolide analogs for the treatment of autoimmune and inflammatory disorders
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Вход / Регистрация
BACKGROUND OF THE INVENTION
Autoimmune and inflammatory diseases affect more than fifty million Americans. The immune system functions as the body's major defense against diseases caused by invading organisms. This complex system fights disease by killing invaders such as bacteria, viruses,
Triptolide analogs for the treatment of autoimmune and inflammatory disorders
Само регистрирани потребители могат да превеждат статии
Вход / Регистрация
FIELD OF THE INVENTION
Background of the Invention
Autoimmune and inflammatory diseases affect more than fifty million Americans. The immune system functions as the body's major defense against diseases caused by invading organisms. This complex system fights disease by killing invaders such as
Triptolide analogs for the treatment of autoimmune and inflammatory disorders
Само регистрирани потребители могат да превеждат статии
Вход / Регистрация
FIELD OF THE INVENTION
The present invention is in the area of pharmaceutical chemistry and specifically relates to novel compounds and pharmaceutical compositions for the treatment of autoimmune and inflammatory disorders. This application claims priority to U.S. patent application Ser. No.
Triptolide prodrugs having high aqueous solubility
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Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to compounds useful as immunosuppressive and anti-inflammatory agents. The compounds have good aqueous solubility and convert to biologically active compounds in vivo.
REFERENCES
Ferrier, R. J. in CARBOHYDRATE CHEMISTRY, Kennedy, J. F., Ed.,
Selecting substances for treating glucocorticoid-mediated inflammation or immune diseases using Tripterygium wilfordii Hook F extracts
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Вход / Регистрация
BACKGROUND OF THE INVENTION
Rheumatoid arthritis (RA) is a chronic inflammatory disease of uncertain etiology. Since the cause is unknown, treatment has been directed at suppressing the signs and symptoms of chronic inflammation. Although many agents have been documented to decrease pain and
Triptolide prodrugs having high aqueous solubility
Само регистрирани потребители могат да превеждат статии
Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to compounds useful as immunosuppressive, anti-inflammatory and anticancer agents. The compounds have good aqueous solubility and convert to biologically active compounds in vivo.
REFERENCES Boyd, G. V. and Heatherington, K., J. Chem. Soc. Perkin
Triptolide 5,6-derivatives as immunomodulators and anticancer agents
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Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to compounds useful as immunosuppressive, anti-inflammatory and anticancer agents.
REFERENCES
Dai, D. et al., U.S. Pat. No. 6,569,893 (2003).
Fidler, J. M. et al., U.S. Pat. No. 6,620,843 (2003).
Gleichmann, E. et al., Immunol. Today 5:324
Triptolide derivatives for modulation of apoptosis and immunosuppression
Само регистрирани потребители могат да превеждат статии
Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to prodrugs useful as immunosuppressive, anti-inflammatory and anticancer agents, and methods of their use. The compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by
Triptolide derivatives for modulation of apoptosis and immunosuppression
Само регистрирани потребители могат да превеждат статии
Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to prodrugs useful as immunosuppressive, anti-inflammatory and anticancer agents, and methods of their use. The compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by
Immunosuppressive compounds and methods
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Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to compounds and methods for use in immunosuppressive and anti-inflammatory treatment.
References
Bradley, L., in SELECTED METHODS IN CELLULAR IMMUNOLOGY, W. H. Freeman and Company, San Francisco, pp. 162-164 (1980).
Briggs, J. D., Immunol. Lett.
Immunosuppressive compounds and methods
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Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to compounds and methods for use in immunosuppressive and anti-inflammatory treatment, and for reducing male fertility.
REFERENCES
Bradley, L., in SELECTED METHODS IN CELLULAR IMMUNOLOGY, W.H. Freeman and Company, San Francisco, pp. 162-164
Tripterygium wilfordii hook F extracts and components, and uses thereof
Само регистрирани потребители могат да превеждат статии
Вход / Регистрация
BACKGROUND OF THE INVENTION
Rheumatoid arthritis (RA) is a chronic inflammatory disease of uncertain etiology. Since the cause is unknown, treatment has been directed at suppressing the signs and symptoms of chronic inflammation. Although many agents have been documented to decrease pain and
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