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urinary incontinence/гадене

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Deuterium-enriched pyridinonecarboxamides and derivatives

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SUMMARY OF THE INVENTION The present invention is concerned with deuterium-enriched pyridinone carboxamides and derivatives thereof of formula I, ##STR00002## Wherein, R.sub.1 and R.sub.2 are independently, H, D (deuterium with enrichment of 1%-100%), F, Cl, CD.sub.3 (methyl-d.sub.3),

Deuterium-enriched pyridinonecarboxamides and derivatives

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SUMMARY OF THE INVENTION The present invention is concerned with deuterium-enriched pyridinonecarboxamides and derivatives thereof of formula 1, ##STR00002## Wherein, R.sub.1 and R.sub.2 are independently, H, D (deuterium with enrichment of 1%-100%), F, Cl, CD.sub.3 (methyl-d.sub.3),

Sulphonamide derivatives, their preparation and their therapeutic application

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FIELD OF THE INVENTION The present invention relates to sulfonamide derivatives, to the process for preparing them and to their therapeutic use. BACKGROUND OF THE INVENTION Orexins A and B (or hypocretins 1 and 2) are hypothalamus neuropeptides of 33 and 28 amino acids, respectively, recently

Thienopyridinone compounds and methods of treatment

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FIELD OF THE INVENTION The invention generally relates to the field of serotonin (5-hydroxytryptamine, or 5-HT) receptor modulators, e.g., agonists, partial agonists, inverse agonists, antagonists, and more particularly to new thienopyridinone compounds, the synthesis and use of these compounds and

Thienopyridinone compounds and methods of treatment

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FIELD OF THE INVENTION The invention generally relates to the field of serotonin (5-hydroxytryptamine, or 5-HT) receptor modulators, e.g., agonists, partial agonists, inverse agonists, antagonists, and more particularly to new thienopyridinone compounds, the synthesis and use of these compounds and

Synthesis of thienopyridinone compounds and related intermediates

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FIELD OF THE INVENTION The invention generally relates to the field of serotonin (5-hydroxytryptamine, or 5-HT) receptor modulators, e.g., agonists, partial agonists, inverse agonists, antagonists, and more particularly to new thienopyridinone compounds, the synthesis and use of these compounds and

N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists

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This application is a 371 of PCT/GB93/02130, Oct. 14, 1993. This invention relates to novel compounds having pharmacological activity, to a process for their preparation and to their use as pharmaceuticals. European Journal of Pharmacology 146 (1988 ), 187-188, and Naunyn-Schmiedeberg's Arch.

Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium

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FIELD OF THE INVENTION The invention pertains to the field of treating patients suffering from various disorders related to various cognitive disorders. More particularly, the invention pertains to alleviating or at least improving upon adverse effects of excessive acetylcholine including, but not

Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium

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FIELD OF THE INVENTION The invention pertains to the field of treating patients suffering from various disorders related to various cognitive disorders. More particularly, the invention pertains to alleviating or at least improving upon adverse effects of excessive acetylcholine including, but not
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