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12 резултата
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.
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Hypoxia inducible factors (HIFs) are ubiquitously expressed transcription factors important for cell homeostasis during dynamic oxygen levels. Myeloid specific HIFs are crucial for aspects of myeloid cell function, including their ability to migrate into inflamed tissues during autoimmune disease.
Anti-inflammatory and ultrastructural effects of Turkish propolis in a rat model of endotoxin-induced uveitis.
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BACKGROUND
Experimental animal models of acute uveitis, an inflammatory eye disease, can be established via endotoxin-induced inflammation. Propolis, a natural substance collected by honeybees from buds and tree exudates, has antioxidant, antibacterial, antiviral, and anti-inflammatory effects. We
Management of uveitis-related choroidal neovascularization: from the pathogenesis to the therapy.
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Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the
[Significance of biochemical values of lacrimal fluid for early diagnosis and prognosis of traumatic uveitis].
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Parameters reflecting the severity of hypoxia and membrane destruction in the lacrimal fluid correlate with the severity of injury to uveal tract tissues.
[The central vitreo-retinal fibroplastic (edematous-fibroplastic) syndrome (author's transl)].
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This term comprises a series of symptoms with a common pathogenesis. The disease begins with disseminated foci of paravascular fibroplasia which are ophthalmoscopically visible as "stationary reflexes" (Vodovozev 1963). These foci result in the formation of vitreo-retinal adhesions. A posterior
Ocular actions of platelet-activating factor: clinical implications.
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BACKGROUND
To summarize the currently available evidence of platelet-activating factor (PAF) implication in the pathogenesis of inflammatory ocular diseases.
METHODS
PAF is a potent mediator of inflammation, implicated in the pathogenesis of chronic inflammatory disorders, allergic reactions,
[Case report: chronic aggressive pulmonary sarcoidosis with bilateral cavitation].
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A 34-year-old male patient was admitted to our hospital because of progressive exertional dyspnea and weight loss (8 kg in one year). Twelve years previously, he had had an episode of uveitis accompanied with bilateral hilar lymphadenopathy. Scalene node biopsy at that time revealed non-caseating
Neovascular glaucoma.
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Neovascular glaucoma is a severe eye disorder classified as a secondary glaucoma and the most common of this type of disease. It is caused by a number of ocular and systemic conditions, which share the common element of retinal ischemia/hypoxia that initiates the subsequent release of angiogenesis
Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?
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Zeaxanthin and lutein are two carotenoid pigments that concentrated in the retina, especially in the macula. The effects of lutein and zeaxanthin on the prevention and treatment of various eye diseases, including age-related macular degeneration, diabetic retinopathy and cataract, ischemic/hypoxia
A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling.
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The angiopoietin (Ang)/Tie2 signaling pathway is essential for maintaining vascular homeostasis, and its dysregulation is associated with several diseases. Interactions between Tie2 and α5β1 integrin have emerged as part of this control; however, the mechanism is incompletely understood. AXT107, a
The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases.
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Lutein (L) and zeaxanthin (Z) are dietary carotenoids derived from dark green leafy vegetables, orange and yellow fruits that form the macular pigment of the human eyes. It was hypothesized that they protect against visual disorders and cognition diseases, such as age-related macular degeneration
Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor.
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Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor. Reduced PEDF levels are associated with diabetic retinopathy. However, the mechanism for the protective effects of PEDF against diabetic retinopathy (DR) is presently unclear. As inflammation plays a role in DR, the present
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