The invention relates to pharmaceutical compositions and methods of preparation thereof suitable for the treatment of neurological, affective and psychotic disorders and for the treatment of pain and migraine comprising as an active ingredient an effective amount of 2-hydroxylpropyl valpormide and a pharmaceutically acceptable carrier or diluent. In a broader sense, the invention concerns 2-hydroxylpropyl valpromide (HP-VPD) of the formula: ##STR1##useful for the treatment of neurological, psychotic and affective disorders, such as convulsions and epilepsy, and for the treatment of pain and migraine.

Yissum Research Development Company of the Hebrew University of Jerusalem

Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation

Alpha-fluorinated alkynoic acids and pharmaceutical compositions containing these compounds are provided, which are useful for the treatment and prevention of seizures such as are associated with epilepsy. The compounds of the invention exhibit reduced side effects, relative to valproic acid, with regard to sedation and teratogenic potential.

valproic acid/епилептични припадъци

Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation

Alpha-fluoro alkynoic acids with anticonvulsant activity

Най-пълната база данни за лечебни билки, подкрепена от науката