wallerian degeneration/астения

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Injury of the corticoreticular pathway in patients with proximal weakness following cerebral infarct: diffusion tensor tractography study.

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The corticoreticular pathway (CRP) innervates mainly the proximal muscles of extremities. Identification of the CRP by diffusion tensor tractography (DTT) in the human brain has recently become possible. However, little is known about the relation between proximal weakness and injury of the CRP in

Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke.

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OBJECTIVE The quantification and clinical significance of WD in CSTs following supratentorial stroke are not well understood. We evaluated the anisotropy by using DTI and signal-intensity changes on conventional MR imaging in the CST to determine whether these findings are correlated with limb motor

Paralytic rabies: a clinico-pathological study.

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Clinical and pathological features of 11 cases of paralytic rabies have been described, with a detailed study of the peripheral nerves. The mean incubation period was forty-nine days (range 7-90 days). The mean interval between the onset of symptoms and death was 8.4 days (range 7-11 days). A

A histopathological analysis of the human cervical spinal cord in patients with acute traumatic central cord syndrome.

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METHODS We have applied conventional histochemical and morphometric techniques to study the changes within the human spinal 'hand' motor neuron pool after spinal cord injury in patients who presented with acute traumatic central cord syndrome (ATCCS). OBJECTIVE To determine whether a reduction of

A lower motor neuron disease in newborn Romney lambs.

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OBJECTIVE To determine the cause and nature of a disease in newborn New Zealand Romney lambs characterised by progressive weakness and premature death. METHODS Affected lambs were examined clinically, humanely killed and submitted to necropsy. Selected fonmalin-fixed tissues were examined

Idiopathic brachial plexus lesion with conduction block of the ulnar nerve.

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A 24-year-old male with idiopathic acute aching of the right wrist, weakness of ulnar innervated muscles of the forearm and hand, and numbness of the ulnar two digits, was examined electrophysiologically. Conduction studies showed almost complete conduction block of motor fibers of the ulnar nerve

Effects of acute and chronic denervation on human myotonia.

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A 32-year-old man with myotonia congenita (Becker type) sustained multiple gunshot wounds. These produced a partial thoracic spinal cord injury and a severe sciatic nerve injury. Six days following the incident, clinical (percussion) and electrophysiologic (EMG) myotonia could be elicited in paretic

Topography of remyelinated chronic spinal cord lesions in herpes simplex virus type 2 infections of mice.

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Six-week-old outbred mice were infected intracerebrally with a low dose of the MS strain of herpes simplex virus type 2. About 1% of neurologically abnormal survivors developed paralysis or severe leg weakness during the first three weeks of infection. Weakness persisted with little subsequent

In vivo analysis of wild-type and FTDP-17 tau transgenic mice.

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Mutations in the coding and intronic regions of the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Some of these mutations lead to an overproduction of tau isoforms with four microtubule-binding repeats, followed by the development of fibrillary lesions

Idiopathic, progressive mononeuropathy in young people.

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We describe six young patients with insidiously progressive, painless weakness in the distribution of a single major lower extremity nerve. No cause could be found despite extensive evaluation, including surgical exploration. At the time of diagnosis, all patients had weakness and three patients had

Changes in nervous tissue in bovine generalized glycogenosis type II.

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Generalized Glycogenosis type II has been diagnosed in seven calves from a herd of cattle maintained at the Murdoch University Veterinary School Farm. The syndromes seen are equivalent to the infantile and childhood forms of the disease in humans. In the brain and spinal cord of the calves acid

Organic arsenic-induced Guillain-Barré-like syndrome due to melarsoprol: a clinical, electrophysiological, and pathological study.

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A young woman suffering from sleeping sickness was treated with melarsoprol. Thirty-eight days after the first administration of this organo-arsenic compound, myalgias, distal paresthesias and rapidly progressive weakness developed in all four limbs. Electrophysiological studies were misleading for

Acute axonal neuropathy in maple syrup urine disease.

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A 25-year-old woman with maple syrup urine disease (MSUD) developed generalized weakness over 1 week. She had severe leg and moderate arm weakness, areflexia, and distal sensory loss. Plasma branched-chain amino acid concentrations were elevated, reflecting an acute exacerbation of the disease.

Ultrastructural changes of compressed lumbar ventral nerve roots following decompression.

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OBJECTIVE To study whether there will be a permanent lumbar nerve root scarring or degeneration secondary to continuous compression followed by decompression on the nerve roots, which can account for postlaminectomy leg weakness or back pain. METHODS The study was performed at the Department of

Compressive cervical myelopathy in young Texel and Beltex sheep.

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BACKGROUND This investigation was prompted by the referral of increasing numbers of young Texel and Beltex rams with ataxia and weakness, or wobbler syndrome. OBJECTIVE The study aims were to describe the clinical and pathologic findings in affected sheep. METHODS The animals evaluated in this study

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