[Reaction of cellular-tissue components of osteogenic sarcoma to the combined action of adriamycin and irradiation].

The study was concerned with the analysis of peculiarities of pathomorphism development in osteogenic sarcoma under different therapeutic modalities. Material was obtained from 229 cases of tumor treated within 1955-1981. Electron microscopic examination of tumor was performed in 20 patients who had had no preoperative treatment and in 3 patients who had received adriamycin intraarterially and distant 60Co teletherapy (total focal dose 36 Gy) prior to surgery. Chondroid zones revealed posttreatment changes similar to spontaneous ones. Degenerative changes displayed by cells of osteo- and fibroplastic zones differed from spontaneous ones. They manifested themselves in the development of "posttreatment forms" with signs of lipophanerosis and hyperpermeability of nuclear and cytoplasmic membranes resulting in cell edema. Rupture of membrane pointed to an irreversible character of cell damage.