Revista da Sociedade Brasileira de Medicina Tropical
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits.
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BACKGROUND
This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis.
METHODS
The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured.
RESULTS
Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity.
CONCLUSIONS
The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.
