Cytoprotective effects of essential oil of Pinus halepensis L. against aspirin-induced toxicity in IEC-6 cells.
Ključne riječi
Sažetak
BACKGROUND
Essential oils from Pinus species have been reported to have various therapeutic properties.
OBJECTIVE
This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro.
METHODS
The cytoprotection of the oil against toxicity of aspirin on the small intestine epithelial cells IEC-6 was tested.
RESULTS
The obtained results have shown that 35 different compounds were identified. Aspirin induced a decrease in cell viability, and exhibited significant damage to their morphology and an increase in superoxide dismutase (SOD) and catalase (CAT) activities. However, the co-treatment of aspirin with the essential oil of Pinus induced a significant increase in cell viability and a decrease in SOD and CAT activities.
CONCLUSIONS
Overall, these finding suggest that the essential oil of Pinus halepensis L. has potent cytoprotective effect against aspirin-induced toxicity in IEC-6 cells.
