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4 ipomeanol/nekroza
Veza se sprema u međuspremnik
12 rezultati
Alterations in alveolar clearance after 4-ipomeanol-induced necrosis of Clara and ciliated cells in the terminal bronchiole of the rat.
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The administration of 4-ipomeanol, [0, 10 (LD), and 25 (HD) mg/kg, ip], to rats resulted in dose-dependent degeneration and necrosis of the nonciliated (Clara) and ciliated epithelial cells of the terminal bronchioles. More extensive necrosis of the terminal bronchiolar epithelium, with exposure of
Ultrastructural morphogenesis of 4-ipomeanol-induced bronchiolitis and interstitial pneumonia in calves.
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The two objectives of this research were 1) to describe the ultrastructural morphogenesis of pulmonary damage and repair induced in calves after treatment with 4-ipomeanol and 2) to characterize infiltrating pulmonary inflammatory cells by bronchoalveolar lavage. Interstitial edema was observed as
An ultrastructural study of bronchiolar lesions in rats induced by 4-ipomeanol, a product from mold-damaged sweet potatoes.
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Repeated intraperitoneal injections of 4-ipomeanol in rats resulted in extensive degeneration and necrosis of nonciliated (Clara) bronchiolar epithelial cells. Subsequently there was necrosis and detachment of ciliated cells from the bronchiolar basal lamina. The remaining nonciliated cells divided
Effects of 3-methylcholanthrene on covalent binding and toxicity of 4-ipomeanol in inducible and non-inducible (B6D2) mice.
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The effects of 3-methylcholanthrene (MC) on the covalent binding and toxicity of 4-ipomeanol (1-(3-furyl)-4-hydroxypentanone, IPO) were studied in (C57BL/6N)(DBA/2N)F1 X DBA/2N backcross (B6D2)D2) mice previously segregated into relatively "inducible" or "non-inducible" groups based on zoxazolamine
Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice.
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The morphogenesis of pulmonary edema and bronchiolar injury induced by the toxic furan, 4-ipomeanol, was studied by combined light and transmission electron microscopy. Weanling male CD-1 mice received 47 mg 4-ipomeanol/kg body weight by intraperitoneal injection and were studied at intervals from 2
Preclinical toxicology studies of 4-ipomeanol: a novel candidate for clinical evaluation in lung cancer.
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4-Ipomeanol (ipomeanol) is being developed as a potential antitumor agent to treat lung cancer. Ipomeanol produced a dose-related toxicity in CD2F1 mice, Fischer 344 rats, and beagle dogs. The LD50 in mice after a single iv dose of ipomeanol was 35 mg/kg in males and 26 mg/kg in females. Minimal
Acute effects of 4-ipomeanol on experimental lung tumors with bronchiolar or alveolar cell features in Syrian hamsters or C3H/HeNCr mice.
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4-Ipomenaol (IPO) has been shown to induce P-450-mediated necrosis of Clara cells in experimental animals, and clinical trials were initiated to treat people with bronchioloalveolar cancers with this novel drug. We therefore performed experiments to examine two different animal lung tumor models for
The nephrotoxicity for mice of deisopropylngaione, a minor furanoid component of toxic myoporaceous essential oils.
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Deisopropylngaione (DIN) is one of a family of hepatotoxic furanosesquiterpenoid essential oils which is found in small amounts (5%) in the leaves of some specimens of the Australian plant Myoporum deserti. DIN differs from other furanoid myoporaceous essential oils in that it also causes lesions in
Toxicity mediated by reactive metabolites of furans.
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Furan derivatives occur widely in the environment, and several of these compounds cause necrosis of target cells within certain organs, including the liver, the kidneys, and the lungs. The tissue specificity may vary from compound to compound. For individual compounds, the specificity may be greatly
The pulmonary clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride.
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Oral administration of carbon tetrachloride to rats or mice caused striking decreases in rat lung microsomal cytochrome P-450 and benzphetamine demethylase activity and in the enzyme-mediated covalent binding of 4-ipomeanol in preparations of rat and mouse lung microsomes, mouse lung slices and
Metabolic basis for the pulmonary Clara cell as a target for pulmonary carcinogenesis.
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The furan compound, 4-ipomeanol, is activated in lung tissue by cytochrome P-450 dependent oxidation to a highly reactive, electrophilic product that binds covalently to tissue macromolecules. Although the reactive metabolite(s) of 4-ipomeanol have not yet been definitively identified, recent
Natural pesticides and bioactive components in foods.
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In this review, some common food plants and their toxic or otherwise bioactive components and mycotoxin contaminants have been considered. Crucifers contain naturally occurring components that are goitrogenic, resulting from the combined action of allyl isothiocyanate, goitrin, and thiocyanate.
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