adenocarcinoma/protease

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LRP1 and Colon Cancer

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Colorectal cancer (CRC) is a major public health problem in France and worldwide. CRC is the third most common cancer in incidence and mortality in France. The vast majority of these cancers are adenocarcinomas that arise sporadically and develop from precursor lesions: adenoma. All CRC with the

Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy

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Several studies have been performed to understand the cellular mechanisms involved in the development of VTE in cancer patients. The pathogenesis of a thrombotic state is linked to the presence of a tumor and is associated with the development of a hypercoagulant state, namely coagulopathy, which

Dose Escalation Study MORAb-066 Targeting TF-expressing Malignancies Including Breast, Pancreatic, Colorectal, NSCLC

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Primary Objective -To evaluate the safety and tolerability of weekly intravenous (IV) infusions of MORAb-066. Secondary Objectives - To identify the dose-limiting toxicities (DLT) and to determine the maximum tolerated dose (MTD) of MORAb-066. - To characterize the pharmacokinetic (PK) properties of

The Roles of Neutrophil Elastase in Lung Cancer

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Objectives 1. To demonstrate the presence of NE in vitro and the entrance into lung adenocarcinoma cells 2. To identify the intracellular mechanisms through which NE mediates its tumor proliferating effects 3. To verify the activation of NE and its related pathway component in clinical lung

Chemotherapy for Lung Cancer in HIV-positive Patients

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The use of tritherapy in developed countries starting in 1996 led to a considerable reduction in AIDS mortality due to opportunistic infections and AIDS-defining cancers. However, increased life expectancies were accompanied by a diversification of the causes of death in HIV-infected individuals. In

Double Blinded Randomized Clinical Trial of the Effect of Open Versus Laparoscopic Colectomy on Neutrophils in Patients With Colon Cancer

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Colorectal cancer is the leading cause of death worldwide. Tumour cell extravasation plays a key role in tumour metastasis. There are evidences tumour cell-leukocyte interactions may support tumour cell invasion and could create an optimal microenvironment for tumour growth at the metastatic site.

Trial of Dasatinib (Sprycel®) in Subjects With Hormone-refractory Prostate Cancer

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Metastatic prostate adenocarcinoma is initially dependent on exogenous androgens for survival and growth; hence, androgen blockade is a key initial intervention for these patients. Whether by orchiectomy or by biochemical blockade, androgen deprivation produces objective regression of prostate

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