asthma/protease

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Cyanamides useful as reversible inhibitors of cysteine proteases

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FIELD OF THE INVENTION This invention relates to cyanamide compounds useful as reversible inhibitors of the cysteine proteases cathepsins S, K, F, L and B. Certain embodiments described are preferable for inhibition of cathepsin K. The compounds are therefore useful in the treatment of cysteine

Mast cell protease peptide inhibitors

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FIELD OF THE INVENTION This invention relates to compositions containing a mast cell protease inhibitor and methods for use thereof in the prevention and treatment of inflammatory disorders mediated by mast cell tryptases. Methods utilizing the compositions for identifying additional inhibitors of

Regulation of human eosinophil serine protease 1-like enzyme

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TECHNICAL FIELD OF THE INVENTION The invention relates to the regulation of a human eosinophil serine protease 1-like enzyme. BACKGROUND OF THE INVENTION Serine proteases are members of a family of proteolytic enzymes characterized by the presence of a cardinal serine in the catalytic site. They

Nitriles useful as reversible inhibitors of cysteine proteases

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FIELD OF THE INVENTION This invention relates to peptidyl carbamates and related compounds. The compounds are reversible inhibitors of the cysteine proteases cathepsins S, K, F, L and B and certain embodiments described are preferable for inhibition of cathepsin K. The compounds are therefore useful

Secretory leukocyte protease inhibitor as an inhibitor of tryptase

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FIELD This invention relates to inhibition of proteases, and more particularly, to inhibition of tryptase by secretory leukocyte protease inhibitor (SLPI). BACKGROUND Vasoactive intestinal peptide (VIP) is a bronchorelaxant which is absent from or present only at relatively low levels in the lungs

Cysteine protease inhibitors

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This application is the national stage of International Application No. PCT/IB2009/055839 filed on Dec. 18, 2009, which claims priority under 35 USC .sctn.119 of Application No. 08172480.9 filed in Europe on Dec. 19, 2008. TECHNICAL FIELD This invention relates to inhibitors of cathepsin S, and

Peptidyl heterocyclic ketones useful as tryptase inhibitors

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FIELD OF THE INVENTION This invention relates to a series of compounds which are peptidyl heterocyclic ketone inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders, skin

Peptidyl heterocyclic ketones useful as tryptase inhibitors

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Compositions and methods for treating mast-cell mediated conditions

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders. The invention includes compositions and methods effective for the prevention and treatment of inflammatory

Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders

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DESCRIPTION OF THE FIELD Tryptase, the predominant protease secreted from human mast cells, is thought to be involved in neuropeptide processing and tissue inflammation. Tryptase concentrations are elevated in the bloodstream for several hours following anaphylaxis (Schwartz et al. (1987) N. Eng. J.

Compositions and methods for treating mast-cell mediated conditions

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Metalloprotease peptide substrates and methods

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FIELD OF THE INVENTION The present invention describes peptide substrates of the metalloproteases ADAM8, ADAM15 and MDC-L. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases. The invention further describes CD23 processing

Method of treatment and agents useful for same

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to a method of inducing, stimulating or otherwise facilitating bronchoprotection in humans and animals by modulating bronchial constriction and/or inflammation. The present invention is predicated in part

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