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14 rezultati
Method of treating a human being for a class of neurological defects and seizure disorders
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BACKGROUND OF THE INVENTION
1. Field of Invention
This invention relates to treatment of human beings for conditions associated with deficiencies in the N-6-trimethyl-L-lysine (TML) pathway affecting biosynthesis of carnitine. Such conditions include: (1) seizures, myoclonic seizures, epilepsy,
Methods of treating developmental disorders with biguanides
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TECHNICAL FIELD
Methods of treating developmental disorders with biguanides are provided.
BACKGROUND
Biguanides such as metformin, buformin and phenformin have been used as antihyperglycemic agents in the treatment of diabetes. Metformin decreases hepatic glucose production, decreases intestinal
Methods of treating developmental disorders with biguanides
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TECHNICAL FIELD
Methods of treating developmental disorders with biguanides are provided.
BACKGROUND
Biguanides such as metformin, buformin and phenformin have been used as antihyperglycemic agents in the treatment of diabetes. Metformin decreases hepatic glucose production, decreases intestinal
KCNQ2 potassium channels
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
DNA encoding rodent KCNQ2 potassium channel
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
KCNQ potassium channels and methods of modulating same
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
KCNQ potassium channels and methods of modulating same
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
Bisarylamines as potassium channel openers
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FIELD OF THE INVENTION
This invention relates to the use of certain bisarylamines as potassium channel openers and to the treatment of diseases modulated by potassium channel opening. Additionally, this invention relates to novel compounds that are useful as potassium channel openers.
BACKGROUND OF
Heterocycles as potassium channel modulators
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BACKGROUND OF THE INVENTION
Ion channels are cellular proteins that regulate the flow of ions, including calcium, potassium, sodium and chloride, into and out of cells. These channels are present in all human cells and affect such processes as nerve transmission, muscle contraction and cellular
Heterocycles as potassium channel modulators
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BACKGROUND OF THE INVENTION
Ion channels are cellular proteins that regulate the flow of ions, including calcium, potassium, sodium and chloride, into and out of cells. These channels are present in all human cells and affect such processes as nerve transmission, muscle contraction and cellular
Heterocycles as potassium channel modulators
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BACKGROUND OF THE INVENTION
Ion channels are cellular proteins that regulate the flow of ions, including calcium, potassium, sodium and chloride, into and out of cells. These channels are present in all human cells and affect such processes as nerve transmission, muscle contraction and cellular
Fused ring heterocycles as potassium channel modulators
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FIELD OF THE INVENTION
This invention relates to the use of certain fused ring heterocycles as potassium channel modulators and to the treatment of diseases in which a potassium channel is implicated. Additionally, this invention relates to novel compounds that are useful as potassium channel
Fused ring heterocycles as potassium channel modulators
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FIELD OF THE INVENTION
This invention relates to the use of certain fused ring heterocycles as potassium channel modulators and to the treatment of diseases in which a potassium channel is implicated. Additionally, this invention relates to novel compounds that are useful as potassium channel
Fused ring heterocycles as potassium channel modulators
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FIELD OF THE INVENTION
This invention relates to the use of certain fused ring heterocycles as potassium channel modulators and to the treatment of diseases in which a potassium channel is implicated. Additionally, this invention relates to novel compounds that are useful as potassium channel
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